Asparagine, a critical limiting metabolite during glutamine starvation Journal Article
| Authors: | Jiang, J.; Pavlova, N. N.; Zhang, J. |
| Article Title: | Asparagine, a critical limiting metabolite during glutamine starvation |
| Abstract: | A challenge of targeting glutamine metabolism in cancer is that tumor cells develop various strategies to adapt to glutamine limitation. We found that asparagine plays a critical role in supporting protein synthesis during glutamine starvation, highlighting a possible approach to optimize the therapeutic efficacy of targeting glutamine metabolism in cancer. © 2018, © 2018 The Author(s). Published with license by Taylor & Francis Group, LLC. © 2018, © Jie Jiang, Natalya N Pavlova, and Ji Zhang. |
| Keywords: | protein synthesis; asparaginase; glutamine; asparagine; tumor metabolism; biology of malignant cells; glutamine synthetase; mechanisms of oncogenesis and tumor progression; novel therapeutic targets; oncogenes and tumor suppressor genes |
| Journal Title: | Molecular and Cellular Oncology |
| Volume: | 5 |
| Issue: | 3 |
| ISSN: | 2372-3556 |
| Publisher: | Taylor & Francis Group |
| Date Published: | 2018-01-01 |
| Start Page: | e1441633 |
| Language: | English |
| DOI: | 10.1080/23723556.2018.1441633 |
| PROVIDER: | scopus |
| PMCID: | PMC6149945 |
| PUBMED: | 30250896 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 4 September 2018 -- Source: Scopus |
