HITTING the diagnosis: Testing for heparin-induced thrombocytopenia in cancer patients Journal Article
| Authors: | Fenelus, M.; Peerschke, E. I. B. |
| Article Title: | HITTING the diagnosis: Testing for heparin-induced thrombocytopenia in cancer patients |
| Abstract: | Objectives To evaluate the use of a pretest probability score (4Ts score) in cancer patients to guide ordering of laboratory screening tests for heparin-induced thrombocytopenia (HIT). Methods A retrospective chart review was conducted for patients (n = 140) in whom laboratory testing for HIT was requested. 4Ts scores were calculated and correlated with heparin-endogenous platelet factor 4 antibody enzyme-linked immunosorbent assay (ELISA) test results. Results All patients with a high pretest probability of HIT (4Ts score = 6-7) had positive ELISA results, compared to 26.1% of patients with intermediate (4Ts score = 4-5) and 4.3% of patients with low (4Ts score ≤3) pretest probability. No patients with 4Ts scores of 2 or less had positive ELISA results. Conclusions HIT can be ruled out in cancer patients (negative predictive value and sensitivity = 100%) with low pretest probability, defined by 4Ts scores of 2 or less, significantly reducing the need for laboratory testing in this patient population. © American Society for Clinical Pathology, 2018. All rights reserved. |
| Keywords: | thrombosis; cost savings; coagulation; hematology; heparin-induced thrombocytopenia; cancer; 4ts score; hit gti-pf4 elisa; laboratory screening; management/administration |
| Journal Title: | American Journal of Clinical Pathology |
| Volume: | 150 |
| Issue: | 2 |
| ISSN: | 0002-9173 |
| Publisher: | Oxford University Press |
| Date Published: | 2018-08-01 |
| Start Page: | 116 |
| End Page: | 120 |
| Language: | English |
| DOI: | 10.1093/ajcp/aqy040 |
| PROVIDER: | scopus |
| PMCID: | PMC6049042 |
| PUBMED: | 29901688 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 4 September 2018 -- Source: Scopus |
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