Sinonasal adenocarcinoma: A rare second malignancy in long term retinoblastoma survivors Journal Article


Authors: Bhagia, P.; Colanta, A. B.; Abramson, D. H.; Carlson, D. L.; Kleinerman, R. A.; Kraus, D.; Dunkel, I. J.
Article Title: Sinonasal adenocarcinoma: A rare second malignancy in long term retinoblastoma survivors
Abstract: Retinoblastoma is the most common primary cancer of the eye in children. The incidence of second tumors in survivors of bilateral retinoblastoma and in survivors of unilateral retinoblastoma who presumably carry a germline RB1 mutation is documented. This article describes the previously unrecognized association of sinonasal adenocarcinoma as a second malignancy in retinoblastoma survivors. We present three cases who received radiation therapy as a part of their treatment and developed sinonasal adenocarcinoma as a second malignancy. Sinonasal adenocarcinoma should be considered as a second malignancy in retinoblastoma survivors who present with vague sinus symptoms. © 2011 Wiley-Liss, Inc.
Keywords: adult; aged; gene mutation; case report; cancer patient; cancer incidence; retinoblastoma; symptom; second cancer; nose carcinoma; rare disease; second malignancy; sinonasal adenocarcinoma
Journal Title: Pediatric Blood and Cancer
Volume: 57
Issue: 4
ISSN: 1545-5009
Publisher: Wiley Periodicals, Inc  
Date Published: 2011-10-01
Start Page: 693
End Page: 695
Language: English
DOI: 10.1002/pbc.23161
PROVIDER: scopus
PUBMED: 21548012
PMCID: PMC3867788
DOI/URL:
Notes: --- - "Export Date: 3 October 2011" - "CODEN: PBCEA" - "Source: Scopus"
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  1. Ira J Dunkel
    371 Dunkel
  2. Dennis Kraus
    268 Kraus
  3. David H Abramson
    389 Abramson
  4. Pooja R Bhagia
    3 Bhagia