Diffusion weighted imaging in predicting progression free survival in patients with squamous cell carcinomas of the head and neck treated with induction chemotherapy Journal Article
| Authors: | Berrak, S.; Chawla, S.; Kim, S.; Quon, H.; Sherman, E.; Loevner, L. A.; Poptani, H. |
| Article Title: | Diffusion weighted imaging in predicting progression free survival in patients with squamous cell carcinomas of the head and neck treated with induction chemotherapy |
| Abstract: | Rationale and Objectives: The aim of this study was to assess the role of diffusion-weighted imaging in predicting progression-free survival in patients with head and neck squamous cell carcinoma (HNSCC) treated with induction chemotherapy. Materials and Methods: Eighteen patients with HNSCC underwent diffusion-weighted imaging studies prior to treatment and within 3 weeks after completion of induction chemotherapy. Median apparent diffusion coefficient (ADC) values were computed from the largest cervical metastatic lymph node. Percentage changes in ADC values from pretreatment to posttreatment time points were compared between alive and dead patients using the Mann-Whitney U test. P values < .05 were considered statistically significant. Results: A 22% increase in ADC was observed after induction chemotherapy in alive patients (n = 15), while patients who died from HNSCC (n = 3) demonstrated a 33% decrease in ADC. The difference in percentage change in ADC between alive and dead patients was significant (P = .039). Conclusions: ADC may be a useful marker in predicting progression-free survival in patients with HNSCC undergoing induction chemotherapy. © 2011 AUR. |
| Keywords: | survival; adult; cancer survival; clinical article; controlled study; treatment outcome; aged; middle aged; survival analysis; cancer surgery; retrospective studies; squamous cell carcinoma; carcinoma, squamous cell; cisplatin; fluorouracil; cancer combination chemotherapy; treatment duration; paclitaxel; cancer patient; cancer radiotherapy; comparative study; lymph node metastasis; lymphatic metastasis; carboplatin; progression free survival; image interpretation, computer-assisted; antineoplastic combined chemotherapy protocols; cetuximab; prediction; cancer mortality; docetaxel; head and neck cancer; head and neck neoplasms; disease progression; predictive value of tests; contrast media; nasopharynx carcinoma; cervical lymph node; gadolinium dtpa; diffusion weighted imaging; diffusion magnetic resonance imaging; statistics, nonparametric; head and neck carcinoma; oropharynx carcinoma; induction chemotherapy; hypopharynx carcinoma; apparent diffusion coefficient; diffusion weighted mri |
| Journal Title: | Academic Radiology |
| Volume: | 18 |
| Issue: | 10 |
| ISSN: | 1076-6332 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2011-10-01 |
| Start Page: | 1225 |
| End Page: | 1232 |
| Language: | English |
| DOI: | 10.1016/j.acra.2011.06.009 |
| PROVIDER: | scopus |
| PMCID: | PMC3168957 |
| PUBMED: | 21835649 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 3 October 2011" - "CODEN: ARADF" - "Source: Scopus" |
