Contemporary results of surgical resection of non-small cell lung cancer after induction therapy: A review of 549 consecutive cases Journal Article


Authors: Barnett, S. A.; Rusch, V. W.; Zheng, J.; Park, B. J.; Rizk, N. P.; Plourde, G.; Bains, M. S.; Downey, R. J.; Shen, R.; Kris, M. G.
Article Title: Contemporary results of surgical resection of non-small cell lung cancer after induction therapy: A review of 549 consecutive cases
Abstract: Objective: We previously reported a high mortality after induction therapy and pneumonectomy for non-small cell lung cancer. Recent reports suggest that operative mortality in these patients is declining. We analyzed our contemporary results to define operative mortality and factors determining surgical risk. Methods: Eligible patients were identified from our prospective surgical database. Complications were graded according to the National Cancer Institute Common Terminology Criteria for Adverse Events 3.0. Uni- and multivariate logistic regression models assessed the association of preoperative tests and clinical characteristics with outcome. Receiver operating characteristic curves and area under the receiver operating characteristic curve (AUC) statistics were calculated in a leave-one-out crossvalidation scheme to evaluate the predictive value of various models. Results: From January 2000 to December 2006, 549 patients underwent surgery after induction therapy. Median patient age was 64 years (range: 30-86), and 54% were women (298/549). All received chemotherapy, and 17% also had radiation. Lobectomy (388/549, 71%) and pneumonectomy (70/549, 13%) were the most common procedures. Complications occurred in 250 patients (46%), with grade 3 or higher in 23% (126/549). Inhospital mortality was 1.8% (10/549), with only one death after right pneumonectomy (1/30, 3%). Multivariate analysis showed that predicted postoperative (PPO) pulmonary function was associated with postoperative morbidity. By receiver operating characteristic curves, PPO product (AUC = 0.75, p < 0.001), PPO diffusion capacity (AUC = 0.70, p < 0.001), and preoperative % predicted PPO diffusion capacity (AUC = 0.66, p < 0.001) predicted mortality. Conclusion: Our current experience shows that resection of non-small cell lung cancer after induction therapy, including pneumonectomy, is associated with low mortality. PPO pulmonary function is the strongest predictor of operative risk and should be used to select patients for surgery. Copyright © 2011 by the International Association for the Study of Lung.
Keywords: adult; cancer chemotherapy; aged; major clinical study; postoperative period; cancer radiotherapy; preoperative care; neoadjuvant therapy; lung non small cell cancer; lung resection; lung cancer; postoperative complication; surgical risk; surgical mortality; lung function test; lobectomy; induction therapy; surgical morbidity and mortality; cisplatin derivative; cancer induction chemotherapy
Journal Title: Journal of Thoracic Oncology
Volume: 6
Issue: 9
ISSN: 1556-0864
Publisher: Elsevier Inc.  
Date Published: 2011-09-01
Start Page: 1530
End Page: 1536
Language: English
DOI: 10.1097/JTO.0b013e318228a0d8
PROVIDER: scopus
PUBMED: 21792074
DOI/URL:
Notes: --- - "Export Date: 3 October 2011" - "Source: Scopus"
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MSK Authors
  1. Junting Zheng
    133 Zheng
  2. Valerie W Rusch
    657 Rusch
  3. Nabil Rizk
    134 Rizk
  4. Ronglai Shen
    129 Shen
  5. Bernard J Park
    156 Park
  6. Robert J Downey
    203 Downey
  7. Manjit S Bains
    229 Bains
  8. Mark Kris
    612 Kris