Management of invasive bladder cancer in patients who are not candidates for or decline cystectomy Journal Article
| Authors: | Balar, A.; Bajorin, D. F.; Milowsky, M. I. |
| Article Title: | Management of invasive bladder cancer in patients who are not candidates for or decline cystectomy |
| Abstract: | Bladder cancer is a common malignancy seen in older adults with coexisting medical illnesses. The management of patients with muscle invasive disease includes perioperative chemotherapy and radical cystectomy; however, patients may decline surgery and older patients with comorbid conditions may not be candidates for surgery and thus alternative treatment strategies are needed. Trimodality bladder preservation protocols for muscle invasive bladder cancer have generally included only those patients who are candidates for a salvage cystectomy. In this review, we discuss the current status of bladder preservation treatment options for patients with muscle-invasive disease who are not candidates for cystectomy or who decline surgery and highlight the need for clinical trials investigating novel treatment approaches in this older patient population. © 2011 The Author(s). |
| Keywords: | cancer chemotherapy; cancer survival; treatment response; overall survival; review; cisplatin; doxorubicin; fluorouracil; cancer combination chemotherapy; monotherapy; multimodality cancer therapy; gemcitabine; paclitaxel; cancer adjuvant therapy; cancer patient; cancer radiotherapy; radiation dose; methotrexate; neurotoxicity; antineoplastic agent; bcg vaccine; carboplatin; cancer immunotherapy; multiple cycle treatment; nephrotoxicity; bone marrow suppression; bladder cancer; vinblastine; radiation response; cancer invasion; survival time; cystectomy; urothelial carcinoma; nausea and vomiting; radiation therapy; clinical decision making; clinical effectiveness; trastuzumab; transurethral resection; transitional cell carcinoma; geriatric assessment; bladder; ototoxicity; bladder preservation; octogenarians; transurethral resection of bladder tumor; turbt |
| Journal Title: | Therapeutic Advances in Urology |
| Volume: | 3 |
| Issue: | 3 |
| ISSN: | 1756-2872 |
| Publisher: | Sage Publications Ltd. |
| Date Published: | 2011-06-01 |
| Start Page: | 107 |
| End Page: | 117 |
| Language: | English |
| DOI: | 10.1177/1756287211407543 |
| PROVIDER: | scopus |
| PMCID: | PMC3159398 |
| PUBMED: | 21904567 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 3 October 2011" - "Source: Scopus" |
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