Beyond cell death: New functions for TNF family cytokines in autoimmunity and tumor immunotherapy Journal Article
| Authors: | Yi, F.; Frazzette, N.; Cruz, A. C.; Klebanoff, C. A.; Siegel, R. M. |
| Article Title: | Beyond cell death: New functions for TNF family cytokines in autoimmunity and tumor immunotherapy |
| Abstract: | Originally discovered as an inducer of apoptosis, the TNF-family receptor Fas (CD95, APO-1, TNFRSF6) has more recently been found to have functions beyond cell death, including T cell co-stimulation and promoting terminal differentiation of CD4+ and CD8+ T cells. Other TNF family members also discovered as apoptosis inducers, such as TRAIL (APO-2L, TNFSF10), can promote inflammation through caspase-8. Surprisingly, non-apoptotic signaling through Fas can protect from the autoimmunity seen in Fas deficiency independently from the cell death inducing functions of the receptor. Non-apoptotic Fas signaling can induce tumor cell growth and migration, and impair the efficacy of T cell adoptive immunotherapy. Blocking of non-apoptotic functions of these receptors may be a novel strategy to regulate autoimmunity and inflammation, and enhance antitumor immunity. © 2018 |
| Keywords: | signal transduction; review; nonhuman; cd8+ t lymphocyte; lymphocyte proliferation; cell death; cancer immunotherapy; apoptosis; inflammation; cell differentiation; cd4+ t lymphocyte; tumor immunity; autoimmunity; tumor necrosis factor receptor; caspase 8; t lymphocyte activation; tumor necrosis factor; necroptosis; human |
| Journal Title: | Trends in Molecular Medicine |
| Volume: | 24 |
| Issue: | 7 |
| ISSN: | 1471-4914 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2018-07-01 |
| Start Page: | 642 |
| End Page: | 653 |
| Language: | English |
| DOI: | 10.1016/j.molmed.2018.05.004 |
| PROVIDER: | scopus |
| PUBMED: | 29880309 |
| PMCID: | PMC7466867 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 1 August 2018 -- Source: Scopus |
