Outcome of children and adolescents with relapsed Hodgkin lymphoma treated with high-dose therapy and autologous stem cell transplantation: The Memorial Sloan Kettering Cancer Center experience Journal Article


Authors: Giulino-Roth, L.; O’Donohue, T.; Chen, Z.; Trippett, T. M.; Klein, E.; Kernan, N. A.; Kobos, R.; Prockop, S. E.; Scaradavou, A.; Shukla, N.; Steinherz, P. G.; Moskowitz, A. J.; Moskowitz, C. H.; Boulad, F.
Article Title: Outcome of children and adolescents with relapsed Hodgkin lymphoma treated with high-dose therapy and autologous stem cell transplantation: The Memorial Sloan Kettering Cancer Center experience
Abstract: To evaluate outcomes and prognostic markers among children with relapsed Hodgkin lymphoma (HL) treated with autologous stem cell transplant (ASCT), we conducted a retrospective analysis of 36 consecutive pediatric patients treated at Memorial Sloan Kettering Cancer Center from 1989 to 2013. With a median follow-up of 9.6 years, the 10-year overall survival (OS) and event-free survival (EFS) were 74.1 and 67.1% respectively. Absence of B-symptoms, chemotherapy-sensitive disease, and transplant date after 1997 were each associated with superior EFS [HR 0.12 (p =.0015), 0.18 (p =.0039), and 0.17 (p =.0208), respectively]. Childhood Hodgkin International Prognostic Score at relapse (R-CHIPS) was calculated in a subset of patients (n = 22) and a lower score was associated with improved OS (HR 0.29, p =.0352) and a trend toward improved EFS (HR 0.38, p =.0527). In summary, ASCT results in durable remission for the majority of pediatric patients with relapsed HL. R-CHIPS should be evaluated in larger cohorts as a potential predictive tool. © 2017, © 2017 Informa UK Limited, trading as Taylor & Francis Group.
Keywords: neoplasia; prognostication; lymphoma and hodgkin disease; clinical results; marrow and stem cell transplantation
Journal Title: Leukemia and Lymphoma
Volume: 59
Issue: 8
ISSN: 1042-8194
Publisher: Taylor & Francis Group  
Date Published: 2018-08-01
Start Page: 1861
End Page: 1870
Language: English
DOI: 10.1080/10428194.2017.1403601
PROVIDER: scopus
PUBMED: 29183202
DOI/URL:
Notes: Article -- Export Date: 1 August 2018 -- Source: Scopus
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MSK Authors
  1. Nancy Kernan
    367 Kernan
  2. Farid Boulad
    243 Boulad
  3. Craig Moskowitz
    367 Moskowitz
  4. Susan E Prockop
    159 Prockop
  5. Lisa B Giulino
    15 Giulino
  6. Alison Moskowitz
    136 Moskowitz
  7. Peter G Steinherz
    160 Steinherz
  8. Rachel Kobos
    65 Kobos
  9. Neerav Shukla
    68 Shukla
  10. Elizabeth Klein
    11 Klein