Synapse - Outcome of children and adolescents with relapsed Hodgkin lymphoma treated with high-dose therapy and autologous stem cell transplantation: The Memorial Sloan Kettering Cancer Center experience

Outcome of children and adolescents with relapsed Hodgkin lymphoma treated with high-dose therapy and autologous stem cell transplantation: The Memorial Sloan Kettering Cancer Center experience Journal Article

Authors:	Giulino-Roth, L.; O’Donohue, T.; Chen, Z.; Trippett, T. M.; Klein, E.; Kernan, N. A.; Kobos, R.; Prockop, S. E.; Scaradavou, A.; Shukla, N.; Steinherz, P. G.; Moskowitz, A. J.; Moskowitz, C. H.; Boulad, F.
Article Title:	Outcome of children and adolescents with relapsed Hodgkin lymphoma treated with high-dose therapy and autologous stem cell transplantation: The Memorial Sloan Kettering Cancer Center experience
Abstract:	To evaluate outcomes and prognostic markers among children with relapsed Hodgkin lymphoma (HL) treated with autologous stem cell transplant (ASCT), we conducted a retrospective analysis of 36 consecutive pediatric patients treated at Memorial Sloan Kettering Cancer Center from 1989 to 2013. With a median follow-up of 9.6 years, the 10-year overall survival (OS) and event-free survival (EFS) were 74.1 and 67.1% respectively. Absence of B-symptoms, chemotherapy-sensitive disease, and transplant date after 1997 were each associated with superior EFS [HR 0.12 (p =.0015), 0.18 (p =.0039), and 0.17 (p =.0208), respectively]. Childhood Hodgkin International Prognostic Score at relapse (R-CHIPS) was calculated in a subset of patients (n = 22) and a lower score was associated with improved OS (HR 0.29, p =.0352) and a trend toward improved EFS (HR 0.38, p =.0527). In summary, ASCT results in durable remission for the majority of pediatric patients with relapsed HL. R-CHIPS should be evaluated in larger cohorts as a potential predictive tool. © 2017, © 2017 Informa UK Limited, trading as Taylor & Francis Group.
Keywords:	neoplasia; prognostication; lymphoma and hodgkin disease; clinical results; marrow and stem cell transplantation
Journal Title:	Leukemia and Lymphoma
Volume:	59
Issue:	8
ISSN:	1042-8194
Publisher:	Taylor & Francis Group
Date Published:	2018-08-01
Start Page:	1861
End Page:	1870
Language:	English
DOI:	10.1080/10428194.2017.1403601
PROVIDER:	scopus
PUBMED:	29183202
PMCID:	PMC6637236
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85035310453&doi=10.1080%2f10428194.2017.1403601&partnerID=40&md5=8af3839d6a76d9ff8fc3ef3378b5aee6
Notes:	Article -- Export Date: 1 August 2018 -- Source: Scopus