The Genomics ADvISER: Development and usability testing of a decision aid for the selection of incidental sequencing results Journal Article

Authors: Bombard, Y.; Clausen, M.; Mighton, C.; Carlsson, L.; Casalino, S.; Glogowski, E.; Schrader, K.; Evans, M.; Scheer, A.; Baxter, N.; Hamilton, J. G.; Lerner-Ellis, J.; Offit, K.; Robson, M.; Laupacis, A.
Article Title: The Genomics ADvISER: Development and usability testing of a decision aid for the selection of incidental sequencing results
Abstract: Guidelines recommend patients be informed of their incidental results (IR) when undergoing genomic sequencing (GS), yet there are limited tools to support patients' decisions about learning IR. The aim of this study is to develop and test the usability of a decision aid (DA) to guide patients' selection of IR, and to describe patients' preferences for learning IR following use of the DA. We developed and evaluated a DA using an iterative, mixed-methods process consisting of (1) prototype development, (2) feasibility testing, (3) cognitive interviews, (4) design and programming, and (5) usability testing. We created an interactive online DA called the Genomics ADvISER, a genomics decision AiD about Incidental SEquencing Results. The Genomics ADvISER begins with an educational whiteboard video, and then engages users in a values clarification exercise, knowledge quiz and final choice step, based on a 'binning' framework. Participants found the DA acceptable and intuitive to use. They were enthusiastic towards GS and IR; all selected multiple categories of IR. The Genomics ADvISER is a new patient-centered tool to support the clinical delivery of incidental GS results. The Genomics ADvISER fills critical care gaps, given the health care system's limited genomics expertise and capacity to convey the large volume of IR and their myriad of implications. © 2018 European Society of Human Genetics.
Keywords: adult; clinical article; gene sequence; videorecording; intensive care; genomics; health care system; incidental finding; decision making; genetic counseling; perception; knowledge; decision support system; patient preference; decision aid; human; male; female; priority journal; article; genomics adviser; incidental result
Journal Title: European Journal of Human Genetics
Volume: 26
Issue: 7
ISSN: 1018-4813
Publisher: Nature Publishing Group  
Date Published: 2018-07-01
Start Page: 984
End Page: 995
Language: English
DOI: 10.1038/s41431-018-0144-0
PROVIDER: scopus
PMCID: PMC6018661
PUBMED: 29703952
Notes: Article -- Export Date: 1 August 2018 -- Source: Scopus
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MSK Authors
  1. Kenneth Offit
    538 Offit
  2. Mark E Robson
    391 Robson