Response to comment on “Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death” Journal Article
| Authors: | Shlezinger, N.; Irmer, H.; Dhingra, S.; Beattie, S. R.; Cramer, R. A.; Braus, G. H.; Sharon, A.; Hohl, T. M. |
| Article Title: | Response to comment on “Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death” |
| Abstract: | Aouacheria et al. question the interpretation of contemporary assays to monitor programmed cell death with apoptosis-like features (A-PCD) in Aspergillus fumigatus. Although our study focuses on fungal A-PCD for host immune surveillance and infectious outcomes, the experimental approach incorporates multiple independent A-PCD markers and genetic manipulations based on fungal rather than mammalian orthologs to circumvent the limitations associated with any single approach. © 2017 The Authors. |
| Keywords: | genetics; animal; mammalia; animals; apoptosis; lung; immunosurveillance; fungus; aspergillus fumigatus; fungi; immunologic surveillance |
| Journal Title: | Science |
| Volume: | 360 |
| Issue: | 6395 |
| ISSN: | 0036-8075 |
| Publisher: | American Association for the Advancement of Science |
| Date Published: | 2018-06-22 |
| Start Page: | eaas9457 |
| Language: | English |
| DOI: | 10.1126/science.aas9457 |
| PUBMED: | 29930111 |
| PROVIDER: | scopus |
| PMCID: | PMC6752710 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 1 August 2018 -- Source: Scopus |
