Multifunctional core-shell nanoplatforms (gold@graphene oxide) with mediated NIR thermal therapy to promote miRNA delivery Journal Article
| Authors: | Assali, A.; Akhavan, O.; Adeli, M.; Razzazan, S.; Dinarvand, R.; Zanganeh, S.; Soleimani, M.; Dinarvand, M.; Atyabi, F. |
| Article Title: | Multifunctional core-shell nanoplatforms (gold@graphene oxide) with mediated NIR thermal therapy to promote miRNA delivery |
| Abstract: | Recent insights into the nanomedicine have revealed that nanoplatforms enhance the efficacy of carrier in therapeutic applications. Here, multifunctional nanoplatforms were utilized in miRNA-101 delivery and NIR thermal therapy to induce apoptosis in breast cancer cells. Au nanorods (NRs) or nanospheres (NSs) covered with graphene oxide (GO) were prepared and functionalized with polyethylene glycol as a stabilizer and poly-L-arginine (P-L-Arg) as a targeting agent. In nanoplatforms, coupling Au@GO prepared stable structures with higher NIR reactivity. P-L-Arg substantially enhanced the cellular uptake and gene retardation of stuffs coated by them. However, rod-shape nanoplatforms indicated better performance in cellular uptake and gene transfection than spherical ones. NIR thermal therapy was implemented to improve gene release and in synergy with miRNA-101 activated the apoptotic pathway and decreased the viability of breast cancer cell (<20%). Briefly, presented delivery systems are potentially efficient in distinguishing cancer cells, miRNA internalization and controlling apoptosis of cancer cells. © 2018 Elsevier Inc. |
| Keywords: | human cell; comparative study; flow cytometry; cell death; cell viability; apoptosis; breast cancer; gene expression; cytotoxicity; rna; genetic transfection; cancer cell; gene therapy; cellular distribution; medical nanotechnology; nanomedicine; real time polymerase chain reaction; amino acids; molecular biology; static electricity; molecular weight; diseases; macrogol; arginine; cancer gene therapy; transmission electron microscopy; infrared devices; mirna; breast cancer cells; surface property; atomic force microscopy; thermography; nanosphere; positive ions; gene delivery system; photothermal therapy; carboxylation; therapeutic application; microrna 101; decomposition; ultraviolet visible spectroscopy; l-arginine; human; female; article; graphene; apoptotic pathways; nanorods; mtt assay; thermogravimetry; gold nanorod; mcf-7 cell line; mda-mb-231 cell line; gold nanoplatform; graphene oxide; poly-l-arginine; gold compounds; stable structures; thermal therapies; polyarginine |
| Journal Title: | Nanomedicine-Nanotechnology Biology and Medicine |
| Volume: | 14 |
| Issue: | 6 |
| ISSN: | 1549-9634 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2018-08-01 |
| Start Page: | 1891 |
| End Page: | 1903 |
| Language: | English |
| DOI: | 10.1016/j.nano.2018.05.016 |
| PROVIDER: | scopus |
| PUBMED: | 29885900 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 August 2018 -- Source: Scopus |
