Transcription factor ETS-1 and reactive oxygen species: Role in vascular and renal injury Journal Article


Authors: Shiu, Y. T.; Jaimes, E. A.
Article Title: Transcription factor ETS-1 and reactive oxygen species: Role in vascular and renal injury
Abstract: The E26 avian erythroblastosis virus transcription factor-1 (ETS-1) is a member of the ETS family and regulates the expression of a variety of genes including growth factors, chemokines and adhesion molecules. Although ETS-1 was discovered as an oncogene, several lines of research show that it is up-regulated by angiotensin II (Ang II) both in the vasculature and the glomerulus. While reactive oxygen species (ROS) are required for Ang II-induced ETS-1 expression, ETS-1 also regulates the expression of p47phox, which is one of the subunits of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase and a major source of ROS in the kidney and vasculature. Thus, there appears to be a positive feedback between ETS-1 and ROS. ETS-1 is also upregulated in the kidneys of rats with salt-sensitive hypertension and plays a major role in the development of end-organ injury in this animal model. Activation of the renin angiotensin system is required for the increased ETS-1 expression in these rats, and blockade of ETS-1 or haplodeficiency reduces the severity of kidney injury in these rats. In summary, ETS-1 plays a major role in the development of vascular and renal injury and is a potential target for the development of novel therapeutic strategies to ameliorate end-organ injury in hypertension. © 2018 by the authors. Licensee MDPI, Basel, Switzerland.
Keywords: vascular injury; reactive oxygen species; renal injury; ets-1
Journal Title: Antioxidants
Volume: 7
Issue: 7
ISSN: 2076-3921
Publisher: MDPI  
Date Published: 2018-07-01
Start Page: 84
Language: English
DOI: 10.3390/antiox7070084
PROVIDER: scopus
PUBMED: 29970819
DOI/URL:
Notes: Review -- Export Date: 1 August 2018 -- Source: Scopus
Altmetric Score
MSK Authors
  1. Edgar Alberto Jaimes
    23 Jaimes