Voriconazole dosing in children younger than 3 years undergoing cancer chemotherapy or hematopoietic stem cell transplantation Journal Article


Authors: Yan, S. Q.; Seyboth, B.; Kobos, R.; Eaton, A.; Seo, S. K.; Cohen, N.
Article Title: Voriconazole dosing in children younger than 3 years undergoing cancer chemotherapy or hematopoietic stem cell transplantation
Abstract: There are limited pediatric population pharmacokinetic data for voriconazole dosing, particularly in younger children. In a cohort of 34 patients younger than 3 years receiving voriconazole, the majority (n = 23, 68%) had a low initial serum concentration <1 mg/L. Among 23 children <2 years old, 19 (83%) had an initial trough <1 mg/L. There was large intra-and interindividual variability in trough levels. Dosing also varied from 3.3 to 19.6 mg/kg per dose. Only 2 of 34 patients had a documented adverse drug reaction attributable to voriconazole. More data are needed to establish optimal dosing in very young children.
Keywords: oncology; safety; children; plasma; therapy; voriconazole; pharmacokinetics
Journal Title: Journal of the Pediatric Infectious Diseases Society
Volume: 7
Issue: 2
ISSN: 2048-7193
Publisher: Oxford University Press  
Date Published: 2018-06-01
Start Page: 169
End Page: 171
Language: English
ACCESSION: WOS:000433878000025
DOI: 10.1093/jpids/pix022
PROVIDER: wos
PMCID: PMC5954300
PUBMED: 28407118
Notes: Article -- Source: Wos
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MSK Authors
  1. Susan Seo
    72 Seo
  2. Anne Austin Eaton
    122 Eaton
  3. Rachel Kobos
    67 Kobos
  4. Brian Michael Seyboth
    11 Seyboth
  5. Qiong   Yan
    7 Yan