Voriconazole dosing in children younger than 3 years undergoing cancer chemotherapy or hematopoietic stem cell transplantation Journal Article
| Authors: | Yan, S. Q.; Seyboth, B.; Kobos, R.; Eaton, A.; Seo, S. K.; Cohen, N. |
| Article Title: | Voriconazole dosing in children younger than 3 years undergoing cancer chemotherapy or hematopoietic stem cell transplantation |
| Abstract: | There are limited pediatric population pharmacokinetic data for voriconazole dosing, particularly in younger children. In a cohort of 34 patients younger than 3 years receiving voriconazole, the majority (n = 23, 68%) had a low initial serum concentration <1 mg/L. Among 23 children <2 years old, 19 (83%) had an initial trough <1 mg/L. There was large intra-and interindividual variability in trough levels. Dosing also varied from 3.3 to 19.6 mg/kg per dose. Only 2 of 34 patients had a documented adverse drug reaction attributable to voriconazole. More data are needed to establish optimal dosing in very young children. |
| Keywords: | oncology; safety; children; plasma; therapy; voriconazole; pharmacokinetics |
| Journal Title: | Journal of the Pediatric Infectious Diseases Society |
| Volume: | 7 |
| Issue: | 2 |
| ISSN: | 2048-7193 |
| Publisher: | Oxford University Press |
| Date Published: | 2018-06-01 |
| Start Page: | 169 |
| End Page: | 171 |
| Language: | English |
| ACCESSION: | WOS:000433878000025 |
| DOI: | 10.1093/jpids/pix022 |
| PROVIDER: | wos |
| PMCID: | PMC5954300 |
| PUBMED: | 28407118 |
| Notes: | Article -- Source: Wos |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work