The role of floxuridine in metastatic liver disease Journal Article
| Authors: | Power, D. G.; Kemeny, N. E. |
| Article Title: | The role of floxuridine in metastatic liver disease |
| Abstract: | Liver metastases are mainly supplied by the hepatic artery. Sustained high levels of intratumoral drug are achievable with certain drugs given via the hepatic artery. Floxuridine (FUDR) is an ideal drug for hepatic arterial infusion (HAI) due to its short half life, steep dose response curve, high total body clearance, and high hepatic extraction. HAI FUDR has consistently shown higher response rates than systemic chemotherapy alone, and some studies have shown a survival advantage. HAI FUDR in combination with systemic chemotherapy has evolved over the years and may be used in palliative, neoadjuvant, and adjuvant settings. The dramatic responses observed with HAI FUDR plus modern era systemic chemotherapy offer the possibility of resection and cure in selected patients. The high hepatic extraction of FUDR limits systemic side effects. Toxicity includes biliary and gastrointestinal ulcers. Copyright © 2009 American Association for Cancer Research. |
| Keywords: | treatment response; overall survival; clinical trial; neutropenia; hepatitis; bevacizumab; cisplatin; doxorubicin; fluorouracil; interferon; diarrhea; liver cell carcinoma; side effect; conference paper; cancer adjuvant therapy; neurotoxicity; colorectal cancer; interleukin 2; controlled clinical trial; liver toxicity; randomized controlled trial; stomatitis; 7 ethyl 10 hydroxycamptothecin; dexamethasone; continuous infusion; irinotecan; aspartate aminotransferase blood level; alkaline phosphatase; aspartate aminotransferase; bilirubin; liver metastasis; folinic acid; stomach ulcer; drug clearance; liver resection; mitomycin c; alkaline phosphatase blood level; bile duct obstruction; kaplan meier method; drug half life; oxaliplatin; floxuridine; bilirubin blood level; drug indication; duodenum ulcer; steatosis |
| Journal Title: | Molecular Cancer Therapeutics |
| Volume: | 8 |
| Issue: | 5 |
| ISSN: | 1535-7163 |
| Publisher: | American Association for Cancer Research |
| Date Published: | 2009-05-01 |
| Start Page: | 1015 |
| End Page: | 1025 |
| Language: | English |
| DOI: | 10.1158/1535-7163.mct-08-0709 |
| PROVIDER: | scopus |
| PUBMED: | 19383854 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 30 November 2010" - "CODEN: MCTOC" - "Source: Scopus" |
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