Unicentric Castleman disease in the mediastinum Journal Article


Authors: Wala, S. J.; Fallon, E. M.; Forlenza, C. J.; Shukla, N.; LaQuaglia, M. P.
Article Title: Unicentric Castleman disease in the mediastinum
Abstract: Castleman disease (CD) is a benign lymphoproliferative disorder that rarely occurs in the pediatric population. This entity arises as either unicentric CD or multicentric CD, and is histopathologically classified as hyaline vascular, plasma cell, or mixed variant. CD is frequently misdiagnosed because it is poorly understood and presents with a variety of symptoms. We present a case of a 15-year-old previously healthy girl with unicentric CD. She presented to an Emergency Department with acute onset of chest pain. Radiographic imaging demonstrated a large right-sided mediastinal mass. Biopsy of the mass demonstrated atypical lymphoid tissue with vascular proliferation and concentric layering of peripheral lymphocytes, consistent with CD, hyaline vascular variant. Following multidisciplinary team discussion, the patient underwent complete resection of the mass. She completely recovered with no evidence of residual or recurrent disease on postoperative imaging. © 2018 The Authors
Keywords: thoracotomy; pediatrics; mediastinal mass; castleman disease; hyaline vascular variant; middle mediastinum
Journal Title: Journal of Pediatric Surgery Case Reports
Volume: 34
ISSN: 2213-5766
Publisher: Elsevier Inc.  
Date Published: 2018-07-01
Start Page: 51
End Page: 53
Language: English
DOI: 10.1016/j.epsc.2018.05.005
PROVIDER: scopus
DOI/URL:
Notes: Article -- Export Date: 2 July 2018 -- Source: Scopus
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MSK Authors
  1. Neerav Shukla
    72 Shukla
  2. Erica Marie Fallon
    1 Fallon
  3. Samantha Jane Wala
    1 Wala