Tumor syndromes predisposing to osteosarcoma Journal Article
| Authors: | Hameed, M.; Mandelker, D. |
| Article Title: | Tumor syndromes predisposing to osteosarcoma |
| Abstract: | Osteosarcoma (OS) is the most common primary bone tumor affecting predominantly adolescents and young adults. It accounts for about 5% of all childhood cancers. Although the majority of OSs are sporadic, a small percentage occur as a component of hereditary cancer syndromes. Early onset, bilateral, multifocal, and metachronous tumors suggest genetic predisposition. The inheritance patterns can be autosomal dominant or recessive. These syndromes predispose to a wide variety of mesenchymal and epithelial cancers with propensity for certain mutations being prevalent in specific cancer subtypes. Li-Fraumeni syndrome, retinoblastoma, Rothmund-Thompson syndrome (type 2), Werner syndrome, and Bloom syndrome, constitute the majority of the tumor syndromes predisposing to OS and will be the focus for this review. © 2018 Wolters Kluwer Health, Inc. All rights reserved. |
| Keywords: | osteosarcoma; cancer predisposition; hereditary syndromes |
| Journal Title: | Advances in Anatomic Pathology |
| Volume: | 25 |
| Issue: | 4 |
| ISSN: | 1072-4109 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2018-07-01 |
| Start Page: | 217 |
| End Page: | 222 |
| Language: | English |
| DOI: | 10.1097/pap.0000000000000190 |
| PROVIDER: | scopus |
| PUBMED: | 29668499 |
| PMCID: | PMC6688172 |
| DOI/URL: | |
| Notes: | Publisher-provided DOI does not resolve (as of 7/24/2018) -- Review -- Export Date: 2 July 2018 -- Source: Scopus |
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