MENIN loss as a tissue-specific driver of tumorigenesis Journal Article

   


Authors: Li, J. W. Y.; Hua, X.; Reidy-Lagunes, D.; Untch, B. R.
Article Title: MENIN loss as a tissue-specific driver of tumorigenesis
Abstract: The MEN1 gene encodes MENIN, a tumor suppressor that plays a role in multiple cellular processes. Germline and somatic mutations in MEN1 have been identified in hereditary and sporadic tumors of neuroendocrine origins suggesting context-specific functions. In this review, we focus on the development of mutational Men1 in vivo models, the known cellular activities of MENIN and efforts to identify vulnerabilities in tumors with MENIN loss. © 2017 Elsevier B.V.
Keywords: tumor suppressor gene; pancreatic neuroendocrine tumor; menin; multiple endocrine neoplasia type 1; men1
Journal Title: Molecular and Cellular Endocrinology
Volume: 469
ISSN: 0303-7207
Publisher: Elsevier Ireland Ltd.  
Date Published: 2018-07-05
Start Page: 98
End Page: 106
Language: English
DOI: 10.1016/j.mce.2017.09.032
PROVIDER: scopus
PUBMED: 28965973
PMCID: PMC8064664
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85030861122&doi=10.1016%2fj.mce.2017.09.032&partnerID=40&md5=783e1994f613234d035672b247ea580d
Notes: Review -- Export Date: 1 June 2018 -- Source: Scopus
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MSK Authors
  1. Diane Lauren Reidy
    294 Reidy
  2. Brian Untch
    65 Untch
  3. Janet Wing Yui Li
    9 Li
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