Ethical issues in non-intervention trials for thyroid cancer Journal Article

Authors: Angelos, P.; Hartl, D. M.; Shah, J. P.; Nixon, I. J.; Owen, R. P.; Rinaldo, A.; Rodrigo, J. P.; Shaha, A. R.; Silver, C. E.; Suárez, C.; Ferlito, A.
Article Title: Ethical issues in non-intervention trials for thyroid cancer
Abstract: In recent years, the increasing numbers of small, apparently indolent thyroid cancers diagnosed in the world have encouraged investigators to consider non-intervention as an alternative to surgical management. In the following pages, the prospect of a non-intervention trial for thyroid cancer is considered with attention to the ethical issues that such a trial might raise. Such a non-intervention trial is analyzed relative to 7 ethical considerations: the social or scientific value of the research, the scientific validity of the trial, the necessity of fair selection of participants, a favorable risk-benefit ratio for trial participants, independent review of the trial, informed consent, and allowing the study participants to withdraw from the trial. A non-intervention trial for thyroid cancer is also considered relative to the central concept of equipoise. © 2017 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology
Keywords: thyroid cancer; clinical trials; ethics; research ethics; equipoise; non-intervention
Journal Title: European Journal of Surgical Oncology
Volume: 44
Issue: 3
ISSN: 0748-7983
Publisher: Elsevier Inc.  
Date Published: 2018-03-01
Start Page: 316
End Page: 320
Language: English
DOI: 10.1016/j.ejso.2017.03.002
PROVIDER: scopus
PUBMED: 28343732
Notes: Article -- Export Date: 1 June 2018 -- Source: Scopus
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MSK Authors
  1. Ashok R Shaha
    553 Shaha
  2. Jatin P Shah
    566 Shah