Ethical issues in non-intervention trials for thyroid cancer Journal Article
| Authors: | Angelos, P.; Hartl, D. M.; Shah, J. P.; Nixon, I. J.; Owen, R. P.; Rinaldo, A.; Rodrigo, J. P.; Shaha, A. R.; Silver, C. E.; Suárez, C.; Ferlito, A. |
| Article Title: | Ethical issues in non-intervention trials for thyroid cancer |
| Abstract: | In recent years, the increasing numbers of small, apparently indolent thyroid cancers diagnosed in the world have encouraged investigators to consider non-intervention as an alternative to surgical management. In the following pages, the prospect of a non-intervention trial for thyroid cancer is considered with attention to the ethical issues that such a trial might raise. Such a non-intervention trial is analyzed relative to 7 ethical considerations: the social or scientific value of the research, the scientific validity of the trial, the necessity of fair selection of participants, a favorable risk-benefit ratio for trial participants, independent review of the trial, informed consent, and allowing the study participants to withdraw from the trial. A non-intervention trial for thyroid cancer is also considered relative to the central concept of equipoise. © 2017 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology |
| Keywords: | thyroid cancer; clinical trials; ethics; research ethics; equipoise; non-intervention |
| Journal Title: | European Journal of Surgical Oncology |
| Volume: | 44 |
| Issue: | 3 |
| ISSN: | 0748-7983 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2018-03-01 |
| Start Page: | 316 |
| End Page: | 320 |
| Language: | English |
| DOI: | 10.1016/j.ejso.2017.03.002 |
| PROVIDER: | scopus |
| PUBMED: | 28343732 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 June 2018 -- Source: Scopus |
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