Visceral thromboses in pancreas adenocarcinoma: Systematic review Journal Article


Authors: Hicks, A. M.; DeRosa, A.; Raj, M.; Do, R.; Yu, K. H.; Lowery, M. A.; Varghese, A.; O'Reilly, E. M.
Article Title: Visceral thromboses in pancreas adenocarcinoma: Systematic review
Abstract: Within gastrointestinal malignancies, primary hepatocellular carcinoma and pancreatic ductal adenocarcinoma (PDAC) are frequently associated with visceral thromboses (VT). Thrombus formation in the portal (PVT), mesenteric (MVT), or splenic vein (SVT) system leads to portal hypertension and intestinal ischemia. VT in PDAC may convey a risk of increased distal thrombosis and poses therapeutic uncertainty regarding the role of anticoagulation. An increasing number of reports describe VT associated with PDAC. It is possible that early diagnosis of these events may help reduce morbidity and speculatively improve oncologic outcomes. To perform a systematic review to study PVT, MVT, and SVT associated with PDAC, and to provide a comprehensive review. Medline/PubMed, Embase, Web of Science, Scopus, and the Cochrane Library. Data Extraction and Assessment: Two blinded independent observers extracted and assessed the studies for diagnosis of PVT, MVT, and SVT in PDAC. Studies were restricted to English-language literature published between 2007 and 2016. Eleven articles were identified. Five case reports and 7 retrospective studies were found, with a total of 127 patients meeting the inclusion criteria. The mean age at diagnosis was 64 years. PVT was found in 35% (n = 46), SVT in 52% (n = 65), and MVT in 13% (n = 15). Mean follow-up time was 26 months. Only 3 of the selected articles studied the impact of anticoagulation in VT. All patients with nonvisceral thrombosis (eg, deep-vein thrombosis, pulmonary emboli) were therapeutically treated; in contrast, patients with VT only rarely received treatment. VT in PDAC is a frequent finding at diagnosis or during disease progression. Evidence to guide treatment choices is limited, and current management is based on inferred experience from nononcologic settings. Anticoagulation appears to be safe in VT, with most of the large studies recommending a careful assessment for patients at a high risk of bleeding. © 2017 Elsevier Inc.
Keywords: portal vein thrombosis; mesenteric vein thrombosis; deep venous thrombosis; splanchnic vein thrombosis; splenic vein thrombosis
Journal Title: Clinical Colorectal Cancer
Volume: 17
Issue: 2
ISSN: 1533-0028
Publisher: Elsevier Inc.  
Date Published: 2018-06-01
Start Page: e207
End Page: e216
Language: English
DOI: 10.1016/j.clcc.2017.12.001
PROVIDER: scopus
PUBMED: 29306522
DOI/URL:
Notes: Review -- Export Date: 1 June 2018 -- Source: Scopus
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MSK Authors
  1. Maeve Aine Lowery
    98 Lowery
  2. Kenneth Ho-Ming Yu
    65 Yu
  3. Kinh Gian Do
    116 Do
  4. Eileen O'Reilly
    324 O'Reilly
  5. Antonio P DeRosa
    32 DeRosa
  6. Micheal Raj
    2 Raj