Validation of an algorithm to predict the likelihood of an 8/8 HLA-matched unrelated donor at search initiation Journal Article


Authors: Davis, E.; Devlin, S.; Cooper, C.; Nhaissi, M.; Paulson, J.; Wells, D.; Scaradavou, A.; Giralt, S.; Papadopoulos, E.; Kernan, N. A.; Byam, C.; Barker, J. N.
Article Title: Validation of an algorithm to predict the likelihood of an 8/8 HLA-matched unrelated donor at search initiation
Abstract: A strategy to rapidly determine if a matched unrelated donor (URD) can be secured for allograft recipients is needed. We sought to validate the accuracy of (1) HapLogic match predictions and (2) a resultant novel Search Prognosis (SP) patient categorization that could predict 8/8 HLA-matched URD(s) likelihood at search initiation. Patient prognosis categories at search initiation were correlated with URD confirmatory typing results. HapLogic-based SP categorizations accurately predicted the likelihood of an 8/8 HLA-match in 830 patients (1530 donors tested). Sixty percent of patients had 8/8 URD(s) identified. Patient SP categories (217 very good, 104 good, 178 fair, 33 poor, 153 very poor, 145 futile) were associated with a marked progressive decrease in 8/8 URD identification and transplantation. Very good to good categories were highly predictive of identifying and receiving an 8/8 URD regardless of ancestry. Europeans in fair/poor categories were more likely to identify and receive an 8/8 URD compared with non-Europeans. In all ancestries very poor and futile categories predicted no 8/8 URDs. HapLogic permits URD search results to be predicted once patient HLA typing and ancestry is obtained, dramatically improving search efficiency. Poor, very poor, andfutile searches can be immediately recognized, thereby facilitating prompt pursuit of alternative donors. © 2017 The American Society for Blood and Marrow Transplantation
Keywords: adult; controlled study; human tissue; allograft; major clinical study; validation process; classification; prediction; allogeneic hematopoietic stem cell transplantation; hla typing; recipient; unrelated donors; european; prognosis; human; male; female; article; search categorization
Journal Title: Biology of Blood and Marrow Transplantation
Volume: 24
Issue: 5
ISSN: 1083-8791
Publisher: Elsevier Inc.  
Date Published: 2018-05-01
Start Page: 1057
End Page: 1062
Language: English
DOI: 10.1016/j.bbmt.2017.12.791
PROVIDER: scopus
PMCID: PMC5953787
PUBMED: 29287807
DOI/URL:
Notes: Article -- Export Date: 1 June 2018 -- Source: Scopus
Altmetric Score
MSK Authors
  1. Nancy Kernan
    382 Kernan
  2. Sergio Andres Giralt
    537 Giralt
  3. Juliet N Barker
    228 Barker
  4. Eric Nelson Davis
    7 Davis
  5. Sean McCarthy Devlin
    305 Devlin
  6. Deborah Sessions Wells
    16 Wells
  7. Candice Jenna Cooper
    4 Cooper