Aggressive versus conventional strategies in the treatment of rectal adenocarcinoma Journal Article
| Authors: | Havenga, K.; Huang, Y.; Enker, W. E.; Welvaart, K.; de Roy van Zuidewijn, D. B. W.; Cohen, A. M. |
| Article Title: | Aggressive versus conventional strategies in the treatment of rectal adenocarcinoma |
| Abstract: | Objective: Comparison of an aggressive approach (including total mesorectal excision and combined modality adjuvant therapy) with a conventional approach in the treatment of primary rectal cancer. Design: Retrospective study. Setting: Memorial Sloan-Kettering Cancer Centre, New York (MSKCC) and University Hospital Leiden, the Netherlands (UHL). Subjects: One hundred and sixty-nine patients treated at MSKCC and 96 patients treated at UHL. Interventions: Total mesorectal excision (MSKCC) and conventional resection (UHL). Main outcome measures: Overall survival and local recurrence-free survival. Results: Five-year overall survival was 73% for MSKCC patients and 52% for UHL patients (P<0.001). Five-year local recurrence-free survival was 83% for MSKCC patients and 72% for UHL patients (P=0.001). Relative risk of dying or developing a local recurrence was 3.37 and 2.61, respectively, for patients treated at UHL compared to patients treated at MSKCC (P<0.001 and P=0.008, respectively). Conclusions: These data suggest that an aggressive approach including total mesorectal excision and combined modality adjuvant therapy improves survival and local control compared to a conventional approach. |
| Keywords: | survival; lymphadenectomy; carcinoma; postoperative radiotherapy; total mesorectal excision; rectal adenocarcinoma; local recurrence; mesorectal excision; low anterior resection; pelvic recurrence; cancer; randomized multicenter |
| Journal Title: | Surgical Oncology |
| Volume: | 5 |
| Issue: | 4 |
| ISSN: | 0960-7404 |
| Publisher: | Elsevier Inc. |
| Date Published: | 1996-08-01 |
| Start Page: | 183 |
| End Page: | 188 |
| Language: | English |
| ACCESSION: | WOS:A1996WL30200005 |
| DOI: | 10.1016/s0960-7404(96)80042-9 |
| PROVIDER: | wos |
| PUBMED: | 9067567 |
| Notes: | Article -- Source: Wos |
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