Brainstem gliomas in children - A Children's Cancer Group review of 119 cases Journal Article


Authors: Kaplan, A. M.; Albright, A. L.; Zimmerman, R. A.; Rorke, L. B.; Li, H.; Boyett, J. M.; Finlay, J. L.; Wara, W. M.; Packer, R. J.
Article Title: Brainstem gliomas in children - A Children's Cancer Group review of 119 cases
Abstract: Brainstem gliomas (BSG) with intrinsic and extensive brainstem involvement continue to have a poor outlook despite current treatment approaches, Neuroimaging studies have aided in the differentiation of malignant brainstem tumors from more 'benign' subgroups. A Children's Cancer Group protocol evaluating outcome in children with BSG after treatment with hyperfractionated radiotherapy (7,200-7,800 cGy) was recently completed. The clinical aspects of 119 children entered into this study were reviewed in an attempt to determine risk groups and prognostic indicators. The overall survival of this group was very poor and there was no statistically significant correlation of survival with age, sex, clinical symptoms and signs, or tumor grade. Longer survival was only associated with prolonged duration of brainstem symptoms and signs greater than 1 month prior to diagnosis of the tumor. Improved outlook for children with BSG will require further research in tumor biology and newer therapeutic modalities.
Keywords: chemotherapy; radiotherapy; tumors; diagnosis; prognostic factors; childhood brain tumors; management; phase-i/ii trial; pediatric-oncology-group; hyperfractionated radiation-therapy; stem gliomas; brainstem gliomas; hyperfractionated radiation therapy
Journal Title: Pediatric Neurosurgery
Volume: 24
Issue: 4
ISSN: 1016-2291
Publisher: Karger  
Date Published: 1996-01-01
Start Page: 185
End Page: 192
Language: English
ACCESSION: WOS:A1996VE18500004
DOI: 10.1159/000121036
PROVIDER: wos
PUBMED: 8873160
Notes: Article -- Source: Wos
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  1. Jonathan Finlay
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