Oral ketamine produces a dose-dependent CNS depression in the rat Journal Article
| Authors: | Shimoyama, M.; Shimoyama, N.; Inturrisi, C. E.; Elliott, K. |
| Article Title: | Oral ketamine produces a dose-dependent CNS depression in the rat |
| Abstract: | The oral to parenteral potency of ketamine to produce central nervous system (CNS) depression was estimated in rats using a behavioral scale. As a function of dose, ketamine produces CNS depression that ranges from ataxia to anesthesia by either route of administration. The oral ED(50) value for ketamine was 120 mg/kg (82.2-159.2, 95% CI) while the intravenous ED(50) value was 3.7 mg/kg (2.4-5.1, 95% CI). Oral ketamine produces CNS effects comparable to intravenous ketamine, although the drug is approximately 32 fold less potent by the oral route. |
| Keywords: | pharmacokinetics; pharmacology; ketamine; biotransformation; metabolites; central nervous system depression; oral administration; liver microsomal preparations |
| Journal Title: | Life Sciences |
| Volume: | 60 |
| Issue: | 1 |
| ISSN: | 0024-3205 |
| Publisher: | Elsevier Inc. |
| Date Published: | 1996-11-22 |
| Start Page: | PL-9 |
| End Page: | PL-14 |
| Language: | English |
| ACCESSION: | WOS:A1996VX72000011 |
| DOI: | 10.1016/s0024-3205(96)00592-9 |
| PROVIDER: | wos |
| PUBMED: | 8995536 |
| Notes: | Article -- Source: Wos |
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