Transcriptional activation of the human p21(WAF1/CIP1) gene by retinoic acid receptor - Correlation with retinoid induction of U937 cell differentiation Journal Article

  

Authors:	Liu, M.; Iavarone, A.; Freedman, L. P.
Article Title:	Transcriptional activation of the human p21(WAF1/CIP1) gene by retinoic acid receptor - Correlation with retinoid induction of U937 cell differentiation
Abstract:	We reported previously that the induced differentiation of the myelomonocytic cell line U937 by vitamin D-3 is facilitated by the transcriptional induction of the p21(WAF1/CIP1) gene by the vitamin D-3 receptor (Liu, M., Lee, M.-H., Cohen, M., and Freedman, L. P. (1996) Genes Dev. 10, 143-158), Retinoic acid (RA), a physiological metabolite of vitamin A, is also a potent inducer of differentiation of several cell types, including myeloid leukemic cells, Like vitamin D-3, RA acts through a subfamily of nuclear hormone receptors, RARs and RXRs (retinoid X receptors), which regulate the expression of target genes by binding to specific DNA elements and modulating transcription initiation. In this report we demonstrate that the gene encoding p21 is also a RA-responsive target gene, and we describe a functional RA response element in this gene's promoter which is required to confer RA induction through RAR . RXR heterodimers. These results correlate the RA induction of monocytic differentiation of U937 cells with the transcriptional activation of the p21 gene and suggest a role for this cyclin/cyclin-dependent kinase complex inhibitor in facilitating this differentiation pathway.
Keywords:	inhibitor; cyclin-dependent kinases; p21; acute promyelocytic leukemia; expression; translocation; tgf-beta; arrest; heterodimers; rar-alpha
Journal Title:	Journal of Biological Chemistry
Volume:	271
Issue:	49
ISSN:	0021-9258
Publisher:	American Society for Biochemistry and Molecular Biology
Date Published:	1996-12-06
Start Page:	31723
End Page:	31728
Language:	English
ACCESSION:	WOS:A1996VW68600107
DOI:	10.1074/jbc.271.49.31723
PROVIDER:	wos
PUBMED:	8940196
Notes:	Article -- Source: Wos

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