Clinical use of posttherapy prostate-specific antigen changes in advanced prostate cancer Conference Paper
| Authors: | Kelly, W. K.; Slovin, S.; Scher, H. I. |
| Title: | Clinical use of posttherapy prostate-specific antigen changes in advanced prostate cancer |
| Conference Title: | Hormone-Refractory Prostate Cancer: An Emerging Epidemic |
| Abstract: | Posttherapy changes in prostate-specific antigen (PSA) have been used as a primary endpoint for patients with prostate cancer in an effort to rapidly identify promising therapeutic approaches. Using this method, agents that do not produce a defined decline in PSA on multiple determinations for a specified period are not to be pursued further. Multiple investigators have used PSA as an outcome measure, but the results are variable and often difficult to interpret. These inconsistences are due to the lack of a consensus on criteria for PSA declines and the inappropriate use of PSA as an endpoint when it is not clinically applicable. Phase III studies are needed to validate any surrogate variable, including posttherapy declines in PSA; until such trials have been performed, investigators need to define and report all parameters of outcome independently. |
| Keywords: | cancer chemotherapy; treatment outcome; androgen; clinical trial; cytotoxic agent; drug efficacy; bone metastasis; conference paper; alpha interferon; antineoplastic agent; prostate specific antigen; etoposide; drug screening; cancer hormone therapy; prostate cancer; prostate-specific antigen; prostatic neoplasms; hydrocortisone; retinoic acid; suramin; bone scintiscanning; neoplasms, hormone-dependent; trimetrexate; estramustine; humans; prognosis; human; male; priority journal |
| Journal Title | Seminars in Oncology |
| Volume: | 23 |
| Issue: | 6 Suppl. 14 |
| Conference Dates: | 1996 May 22 |
| Conference Location: | Philadelphia, PA |
| ISBN: | 0093-7754 |
| Publisher: | Elsevier Inc. |
| Date Published: | 1996-12-01 |
| Start Page: | 8 |
| End Page: | 14 |
| Language: | English |
| PUBMED: | 8996578 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Conference Paper -- Export Date: 22 November 2017 -- Source: Scopus |
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