The targeting and assembly of peroxisomal proteins: Some old rules do not apply Journal Article
| Authors: | McNew, J. A.; Goodman, J. M. |
| Article Title: | The targeting and assembly of peroxisomal proteins: Some old rules do not apply |
| Abstract: | Several proteins have been identified that catalyze the import of proteins into peroxisomes. Some recognize specific peroxisomal targeting sequences, but most probably work further downstream the import pathway. Recent evidence suggests that peroxisomal targeting and assembly do not follow the same rules as those for targeting and import into other organelles, such as the mitochondria and the endoplasmic reticulum, i.e. the import of unfolded proteins and subsequent folding within the organelle. Specifically, proteins may be translocated into the peroxisomal matrix in a folded or oligomerized state. |
| Keywords: | carrier protein; genetics; mutation; review; metabolism; gene expression; biological model; models, biological; membrane proteins; chemistry; saccharomyces cerevisiae; carrier proteins; membrane protein; cell membrane; protein folding; biological transport; receptors, cytoplasmic and nuclear; transport at the cellular level; cell receptor; chloramphenicol acetyltransferase; chloramphenicol o-acetyltransferase; microbodies; peroxisomal targeting signal 2 receptor; peroxisome targeting signal 1 receptor; peroxisome-targeting signal 1 receptor; microbody |
| Journal Title: | Trends in Biochemical Sciences |
| Volume: | 21 |
| Issue: | 2 |
| ISSN: | 0968-0004 |
| Publisher: | Elsevier Inc. |
| Date Published: | 1996-02-01 |
| Start Page: | 54 |
| End Page: | 58 |
| Language: | English |
| DOI: | 10.1016/S0968-0004(96)80181-2 |
| PUBMED: | 8851661 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Export Date: 22 November 2017 -- Source: Scopus |
