Biology and management of AIDS-associated primary CNS lymphomas Journal Article
| Authors: | Forsyth, P. A.; DeAngelis, L. M. |
| Article Title: | Biology and management of AIDS-associated primary CNS lymphomas |
| Abstract: | Primary central nervous system (CNS) lymphoma is the most common brain tumor in patients with AIDS and occurs in about 10% of this population. CT/MR scan usually demonstrates single or multiple contrast enhancing masses that are radiographically indistinguishable from other CNS processes such as toxoplasmosis. Brain biopsy, positive cerebrospinal fluid (CSF) cytology, or possibly the demonstration of Epstein-Barr vital DNA in the CSF can establish the diagnosis. Cranial radiotherapy (RT) has been the cornerstone of therapy and produces responses in most patients, but their median survival is still only a few months. The addition of chemotherapy to RT may prolong survival in a sub group of patients. |
| Keywords: | cancer survival; clinical feature; review; cytarabine; methotrexate; brain radiation; nuclear magnetic resonance imaging; brain tumor; computer assisted tomography; vincristine; lomustine; procarbazine; thiotepa; central nervous system tumor; nonhodgkin lymphoma; contrast enhancement; lymphoma; acquired immune deficiency syndrome; meningioma; brain biopsy; epstein barr virus; cerebrospinal fluid cytology; toxoplasmosis; virus dna; priority journal |
| Journal Title: | Hematology/Oncology Clinics of North America |
| Volume: | 10 |
| Issue: | 5 |
| ISSN: | 0889-8588 |
| Publisher: | Elsevier Inc. |
| Date Published: | 1996-10-01 |
| Start Page: | 1125 |
| End Page: | 1134 |
| Language: | English |
| DOI: | 10.1016/s0889-8588(05)70388-9 |
| PUBMED: | 8880200 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Export Date: 22 November 2017 -- Source: Scopus |
