Pathogenesis and management of acute promyelocytic leukemia Journal Article
| Author: | Warrell, R. P. Jr |
| Article Title: | Pathogenesis and management of acute promyelocytic leukemia |
| Abstract: | Acute promyelocytic leukemia, formerly a highly lethal disease, was recently shown to be highly responsive to treatment with the natural retinoid, all-trans retinoic acid. This compound induces terminal differentiation of the malignant cells and produces complete remission in most patients with this disease. The clinical response is due in part to the presence of a chromosomal break that occurs in a gene that encodes a nuclear retinoic acid receptor. |
| Keywords: | pathogenesis; review; drug efficacy; skin toxicity; neurotoxicity; lung toxicity; blood toxicity; gastrointestinal symptom; maintenance therapy; cell differentiation; leukemia, promyelocytic, acute; cardiotoxicity; cancer cell; acute myeloblastic leukemia; remission; remission induction; chromosome breakage; chromosome aberrations; metabolic disorder; retinoic acid; differentiation; retinoic acid receptor; tretinoin; receptors, retinoic acid; all-trans retinoic acid; antileukemic agent; retinoic acid receptors; humans; human; priority journal |
| Journal Title: | Annual Review of Medicine |
| Volume: | 47 |
| ISSN: | 0066-4219 |
| Publisher: | Annual Reviews |
| Date Published: | 1996-01-01 |
| Start Page: | 555 |
| End Page: | 565 |
| Language: | English |
| DOI: | 10.1146/annurev.med.47.1.555 |
| PUBMED: | 8712802 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Export Date: 22 November 2017 -- Source: Scopus |
