Rapid autopsy of a patient with recurrent anaplastic ependymoma Journal Article

   


Authors: Lange, K. R.; Fischer, C.; Rajappa, P.; Connors, S.; Pisapia, D.; Greenfield, J. P.; Beltran, H.; Rubin, M.; Mosquera, J. M.; Khakoo, Y.
Article Title: Rapid autopsy of a patient with recurrent anaplastic ependymoma
Abstract: Objective: Our aim was to outline a procedure for obtaining a rapid autopsy in order to collect high-quality postmortem tissue for genomic analysis.Methods: This report details a bi-institutional collaborative effort to coordinate a rapid autopsy for a pediatric patient who had died at home. We discuss the scientific rationale for offering a rapid autopsy to caregivers of pediatric patients as well as parental perspectives on broaching the subject of autopsy. We then review the logistics and coordination involved with planning a rapid autopsy and the sequence of events needed to maximize tissue quality.Results: We report the successful coordination of a rapid autopsy for a patient who died in a hospice setting at her out-of-state home. The time interval from death to the start of the rapid autopsy procedure was 4.5 hours, despite the logistical considerations demanded by the location of the patient. Tumor aliquots and nonneoplastic tissues were successfully snap frozen for downstream genomic studies.Significance of Results: Physicians should consider trialing a rapid autopsy program at their institution that could be offered to caregivers of pediatric patients. This case report offers a framework to help clinicians develop their own rapid autopsy programs as well as guidelines to help streamline this process for appropriate candidates going forward. Copyright © Cambridge University Press 2017.
Keywords: pediatric; communication; autopsy; hospice; neurooncology
Journal Title: Palliative and Supportive Care
Volume: 16
Issue: 2
ISSN: 1478-9515
Publisher: Cambridge University Press  
Date Published: 2018-04-01
Start Page: 238
End Page: 242
Language: English
DOI: 10.1017/s1478951517000864
PROVIDER: scopus
PUBMED: 28942746
PMCID: PMC5977387
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85030855322&doi=10.1017%2fS1478951517000864&partnerID=40&md5=02c763ad6f26dbea4d91eed52f7f5155
Notes: Article -- Export Date: 1 May 2018 -- Source: Scopus
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MSK Authors
  1. Yasmin Khakoo
    149 Khakoo
  2. Cheryl Melissa Fischer
    13 Fischer
  3. Jeffrey Peter Greenfield
    39 Greenfield
  4. Katharine Newcomb Rae
    7 Rae
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