Influence of obesity-related risk factors in the aetiology of glioma Journal Article

Authors: Disney-Hogg, L.; Sud, A.; Law, P. J.; Cornish, A. J.; Kinnersley, B.; Ostrom, Q. T.; Labreche, K.; Eckel-Passow, J. E.; Armstrong, G. N.; Claus, E. B.; Il'yasova, D.; Schildkraut, J.; Barnholtz-Sloan, J. S.; Olson, S. H.; Bernstein, J. L.; Lai, R. K.; Swerdlow, A. J.; Simon, M.; Hoffmann, P.; Nöthen, M. M.; Jöckel, K. H.; Chanock, S.; Rajaraman, P.; Johansen, C.; Jenkins, R. B.; Melin, B. S.; Wrensch, M. R.; Sanson, M.; Bondy, M. L.; Houlston, R. S.
Article Title: Influence of obesity-related risk factors in the aetiology of glioma
Abstract: Background: Obesity and related factors have been implicated as possible aetiological factors for the development of glioma in epidemiological observation studies. We used genetic markers in a Mendelian randomisation framework to examine whether obesity-related traits influence glioma risk. This methodology reduces bias from confounding and is not affected by reverse causation. Methods: Genetic instruments were identified for 10 key obesity-related risk factors, and their association with glioma risk was evaluated using data from a genome-wide association study of 12,488 glioma patients and 18,169 controls. The estimated odds ratio of glioma associated with each of the genetically defined obesity-related traits was used to infer evidence for a causal relationship. Results: No convincing association with glioma risk was seen for genetic instruments for body mass index, waist-to-hip ratio, lipids, type-2 diabetes, hyperglycaemia or insulin resistance. Similarly, we found no evidence to support a relationship between obesity-related traits with subtypes of glioma-glioblastoma (GBM) or non-GBM tumours. Conclusions: This study provides no evidence to implicate obesity-related factors as causes of glioma. © 2018 The Author(s).
Journal Title: British Journal of Cancer
Volume: 118
Issue: 7
ISSN: 0007-0920
Publisher: Nature Publishing Group  
Date Published: 2018-04-01
Start Page: 1020
End Page: 1027
Language: English
DOI: 10.1038/s41416-018-0009-x
PROVIDER: scopus
PUBMED: 29531326
Notes: Article -- Export Date: 1 May 2018 -- Source: Scopus
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MSK Authors
  1. Sara H Olson
    212 Olson
  2. Jonine L Bernstein
    103 Bernstein