Factors associated with a primary surgical approach for sinonasal squamous cell carcinoma Journal Article
| Authors: | Cracchiolo, J. R.; Patel, K.; Migliacci, J. C.; Morris, L. T.; Ganly, I.; Roman, B. R.; McBride, S. M.; Tabar, V. S.; Cohen, M. A. |
| Article Title: | Factors associated with a primary surgical approach for sinonasal squamous cell carcinoma |
| Abstract: | Background and Objectives: Primary surgery is the preferred treatment of T1-T4a sinonasal squamous cell carcinoma (SNSCC). Methods: Patients with SNSCC in the National Cancer Data Base (NCDB) were analyzed. Factors that contributed to selecting primary surgical treatment were examined. Overall survival (OS) in surgical patients was analyzed. Results: Four-thousand seven hundred and seventy patients with SNSCC were included. In T1-T4a tumors, lymph node metastases, maxillary sinus location, and treatment at high-volume centers were associated with selecting primary surgery. When primary surgery was utilized, tumor factors and positive margin guided worse OS. Adjuvant therapy improved OS in positive margin resection and advanced T stage cases. Conclusions: Tumor and non-tumor factors are associated with selecting surgery for the treatment of SNSCC. When surgery is selected, tumor factors drive OS. Negative margin resection should be the goal of a primary surgical approach. When a positive margin resection ensues, adjuvant therapy may improve OS. © 2017 Wiley Periodicals, Inc. |
| Keywords: | adult; cancer survival; aged; aged, 80 and over; middle aged; cancer surgery; survival rate; major clinical study; overall survival; cancer localization; squamous cell carcinoma; carcinoma, squamous cell; adjuvant therapy; cancer patient; cancer staging; lymph node metastasis; neoplasm staging; cohort studies; cohort analysis; age factors; pathology; surgical approach; age; correlation analysis; head and neck neoplasms; paranasal sinus cancer; paranasal sinus neoplasms; head and neck tumor; correlational study; surgical patient; nose cancer; paranasal sinus tumor; surgical margin; clinical outcome; maxillary sinus; margin status; treatment selection; adjuvant chemoradiotherapy; chemoradiotherapy, adjuvant; very elderly; humans; human; male; female; priority journal; article; margins of excision; sinonasal squamous cell carcinoma (snscc); sinonasal squamous cell carcinoma |
| Journal Title: | Journal of Surgical Oncology |
| Volume: | 117 |
| Issue: | 4 |
| ISSN: | 0022-4790 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2018-03-15 |
| Start Page: | 756 |
| End Page: | 764 |
| Language: | English |
| DOI: | 10.1002/jso.24923 |
| PUBMED: | 29193098 |
| PROVIDER: | scopus |
| PMCID: | PMC5878715 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 May 2018 -- Source: Scopus |
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