The molecular pathology of cancer: from pan-genomics to post-genomics Journal Article


Authors: Huntsman, D. G.; Ladanyi, M.
Article Title: The molecular pathology of cancer: from pan-genomics to post-genomics
Abstract: As the cancer genomics of most major cancer types have been comprehensively catalogued over the past decade through a variety of national and international efforts, the delineation of cancer subtypes has been refined, and our understanding of critical cancer drivers and of the potentially targetable vulnerabilities that they create has grown tremendously. The 2018 Annual Review Issue of the Journal of Pathology provides in-depth assessments of how these pan-genomic approaches have enabled advances in cancer classification, targeted therapy selection, and assessment of cancer progression, all of which are now genomically informed, using several cancer types as examples. Beyond these areas of by now conventional pan-genomic tumour analysis, there are also reviews of diverse ‘post-genomic’ areas, such as the analysis of circulating free tumour DNA in plasma, concurrent germline cancer predisposition profiling in the setting of apparently sporadic cancer, genetic alterations in epigenetic control and DNA repair, proteomics of tumour heterogeneity, computational pathology, and the roles of the cellular stress response and the microbiome in human cancers. As we are able to derive more and more biologically useful information from diverse human biospecimens, these many advances are informing and transforming the practice of cancer pathology. Copyright © 2018 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. Copyright © 2018 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Keywords: cancer genomics; molecular pathology; neoplasia
Journal Title: Journal of Pathology
Volume: 244
Issue: 5
ISSN: 0022-3417
Publisher: Wiley Blackwell  
Date Published: 2018-04-01
Start Page: 509
End Page: 511
Language: English
DOI: 10.1002/path.5057
PROVIDER: scopus
PUBMED: 29436707
DOI/URL:
Notes: Review -- Export Date: 1 May 2018 -- Source: Scopus
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  1. Marc Ladanyi
    1328 Ladanyi