Quantification of iodine concentration using single-source dual-energy computed tomography in a calf liver Journal Article

   

Authors:	Agostini, A.; Mahmood, U.; Erdi, Y.; Borgheresi, A.; Ragucci, M.; Sawan, P.; Ryan, D.; Laino, M. E.; Corrias, G.; Mannelli, L.
Article Title:	Quantification of iodine concentration using single-source dual-energy computed tomography in a calf liver
Abstract:	Objective To evaluate the accuracy of single-source dual-energy computed tomography (ssDECT) in iodine quantification using various segmentation methods in an ex vivo model. Methods Ten sausages, injected with variable quantities of iodinated contrast, were inserted into 2 livers and scanned with ssDECT. Material density iodine images were reconstructed. Three radiologists segmented each sausage. Iodine concentration, volume, and absolute quantity were measured. Agreement between the measured and injected iodine was assessed with the concordance correlation coefficient (CCC). Intrareader agreement was assessed using the intraclass correlation coefficient (ICC). Results Air bubbles were observed in sausage (IX). Sausage (X) was within the same view as hyper-attenuating markers used for localization. With IX and X excluded, CCC and ICC were greater than 0.98 and greater than 0.88. When included, CCC and ICC were greater than 0.94 and greater than 0.79. Conclusions Iodine quantification was reproducible and precise. However, accuracy reduced in sausages consisting of air filled cavities and within the same view as hyperattenuating markers. © 2017 Wolters Kluwer Health, Inc. All rights reserved.
Keywords:	controlled study; nonhuman; reproducibility; reproducibility of results; animal; animals; animal tissue; tomography, x-ray computed; diagnostic imaging; liver; iohexol; radiography; cattle; ex vivo study; iodine; meat; chicken; procedures; bovine; priority journal; article; x-ray computed tomography; dect; iodine quantification; rapid switching; calf (bovine); dual energy computed tomography; radiography, dual-energy scanned projection
Journal Title:	Journal of Computer Assisted Tomography
Volume:	42
Issue:	2
ISSN:	0363-8715
Publisher:	Lippincott Williams & Wilkins
Date Published:	2018-03-01
Start Page:	222
End Page:	229
Language:	English
DOI:	10.1097/rct.0000000000000685
PUBMED:	29489589
PROVIDER:	scopus
PMCID:	PMC5847415
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85044408684&doi=10.1097%2fRCT.0000000000000685&partnerID=40&md5=1776a76ec867655de1d8ca568f63691c
Notes:	Article -- Export Date: 1 May 2018 -- Source: Scopus

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