The murine natural cytotoxic receptor NKp46/NCR1 controls TRAIL protein expression in NK cells and ILC1s Journal Article

   


Authors: Sheppard, S.; Schuster, I. S.; Andoniou, C. E.; Cocita, C.; Adejumo, T.; Kung, S. K. P.; Sun, J. C.; Degli-Esposti, M. A.; Guerra, N.
Article Title: The murine natural cytotoxic receptor NKp46/NCR1 controls TRAIL protein expression in NK cells and ILC1s
Abstract: TRAIL is an apoptosis-inducing ligand constitutively expressed on liver-resident type 1 innate lymphoid cells (ILC1s) and a subset of natural killer (NK) cells, where it contributes to NK cell anti-tumor, anti-viral, and immunoregulatory functions. However, the intrinsic pathways involved in TRAIL expression in ILCs remain unclear. Here, we demonstrate that the murine natural cytotoxic receptor mNKp46/NCR1, expressed on ILC1s and NK cells, controls TRAIL protein expression. Using NKp46-deficient mice, we show that ILC1s lack constitutive expression of TRAIL protein and that NK cells activated in vitro and in vivo fail to upregulate cell surface TRAIL in the absence of NKp46. We show that NKp46 regulates TRAIL expression in a dose-dependent manner and that the reintroduction of NKp46 in mature NK cells deficient for NKp46 is sufficient to restore TRAIL surface expression. These studies uncover a link between NKp46 and TRAIL expression in ILCs with potential implications in pathologies involving NKp46-expressing cells. Sheppard et al. find that mice deficient in the activating receptor NCR1/NKp46 (Ncr1−/−) fail to express the apoptosis-inducing ligand TRAIL at the surface of group 1 innate lymphoid cells (ILC1s). © 2018 The Authors
Keywords: natural killer cell; il-2; trail; il-15; nk cell; ilc1; nkp46
Journal Title: Cell Reports
Volume: 22
Issue: 13
ISSN: 2211-1247
Publisher: Cell Press  
Date Published: 2018-03-27
Start Page: 3385
End Page: 3392
Language: English
DOI: 10.1016/j.celrep.2018.03.023
PROVIDER: scopus
PMCID: PMC5896200
PUBMED: 29590608
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85044296838&doi=10.1016%2fj.celrep.2018.03.023&partnerID=40&md5=d7928959f41df98108c54429a12f0238
Notes: Article -- Export Date: 1 May 2018 -- Source: Scopus
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MSK Authors
  1. Joseph C Sun
    135 Sun
  2. Sam Sheppard
    10 Sheppard
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