Smartphone confocal microscopy for imaging cellular structures in human skin in vivo Journal Article
| Authors: | Freeman, E. E.; Semeere, A.; Osman, H.; Peterson, G.; Rajadhyaksha, M.; González, S.; Martin, J. N.; Rox Anderson, R.; Tearney, G. J.; Kang, D. |
| Article Title: | Smartphone confocal microscopy for imaging cellular structures in human skin in vivo |
| Abstract: | We report development of a low-cost smartphone confocal microscope and its first demonstration of in vivo human skin imaging. The smartphone confocal microscope uses a slit aperture and diffraction grating to conduct two-dimensional confocal imaging without using any beam scanning devices. Lateral and axial resolutions of the smartphone confocal microscope were measured as 2 and 5 µm, respectively. In vivo confocal images of human skin revealed characteristic cellular structures, including spinous and basal keratinocytes and papillary dermis. Results suggest that the smartphone confocal microscope has a potential to examine cellular details in vivo and may help disease diagnosis in resource-poor settings, where conducting standard histopathologic analysis is challenging. © 2018 Optical Society of America. |
| Keywords: | microscopes; skin; diagnosis; confocal imaging; axial resolutions; confocal image; papillary dermis; cellular structure; disease diagnosis; human skin in vivo; cellular automata; in-vivo human skin; smartphones |
| Journal Title: | Biomedical Optics Express |
| Volume: | 9 |
| Issue: | 4 |
| ISSN: | 2156-7085 |
| Publisher: | Optical Society of America |
| Date Published: | 2018-01-01 |
| Start Page: | 1906 |
| End Page: | 1915 |
| Language: | English |
| DOI: | 10.1364/boe.9.001906 |
| PROVIDER: | scopus |
| PMCID: | PMC5905933 |
| PUBMED: | 29675328 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 May 2018 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
MSK Authors
-
222Rajadhyaksha -
29Peterson
Related MSK Work