Effective prostate-specific membrane antigen-based (18)F-DCFPyL-guided cryoablation of a single positive site in a patient believed to be more metastatic on (11)C-choline PET/CT Journal Article
| Authors: | Cornelis, F. H.; Durack, J. C.; Morris, M. J.; Scher, H. I.; Solomon, S. B. |
| Article Title: | Effective prostate-specific membrane antigen-based (18)F-DCFPyL-guided cryoablation of a single positive site in a patient believed to be more metastatic on (11)C-choline PET/CT |
| Abstract: | PET/CT-guided interventions using specific radiotracers are promising for detecting avid lesions not well visualized with other imaging methods. A 72-year-old man who initially presented with prostate cancer Gleason 5 + 4 (prostate-specific antigen [PSA] = 7.9 ng/mL) underwent radical prostatectomy and node dissection. Three years after radiation, a rising PSA was observed over 6 months with PSA level reaching 1.08 ng/mL. He was evaluated with prostate-specific membrane antigen-based (PSMA) F-DCFPyL PET/CT, conventional CT, F-FDG PET/CT, and C-choline PET/CT. The PSMA F-DCFPyL PET/CT successfully targeted oligometastatic prostate cancer, whereas the other imaging studies were not correct in assessing disease extent. |
| Keywords: | aged; case report; metabolism; metastasis; pathology; diagnostic imaging; prostatic neoplasms; membrane antigen; prostate tumor; neoplasm metastasis; choline; lysine; cryosurgery; glutamate carboxypeptidase ii; glutamate carboxypeptidase ii, human; antigens, surface; carbon; surgery, computer-assisted; urea; computer assisted surgery; carbon radioisotopes; carbon-11; humans; human; male; analogs and derivatives; positron emission tomography-computed tomography; positron emission tomography computed tomography; 2-(3-(1-carboxy-5-((6-fluoropyridine-3-carbonyl)amino)pentyl)ureido)pentanedioic acid |
| Journal Title: | Clinical Nuclear Medicine |
| Volume: | 42 |
| Issue: | 12 |
| ISSN: | 0363-9762 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2017-12-01 |
| Start Page: | e516 |
| End Page: | e518 |
| Language: | English |
| DOI: | 10.1097/rlu.0000000000001846 |
| PUBMED: | 29099733 |
| PROVIDER: | scopus |
| PMCID: | PMC5736003 |
| DOI/URL: | |
| Notes: | Article -- This is one of several "interesting images" that the journal published in this issue -- Export Date: 1 May 2018 -- Source: Scopus |
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