Impact of the tumor microenvironment on tumor-infiltrating lymphocytes: Focus on breast cancer Journal Article
| Authors: | Cohen, I. J.; Blasberg, R. |
| Article Title: | Impact of the tumor microenvironment on tumor-infiltrating lymphocytes: Focus on breast cancer |
| Abstract: | Immunotherapy is revolutionizing cancer care across disciplines. The original success of immune checkpoint blockade in melanoma has already been translated to Food and Drug Administration–approved therapies in a number of other cancers, and a large number of clinical trials are underway in many other disease types, including breast cancer. Here, we review the basic requirements for a successful antitumor immune response, with a focus on the metabolic and physical barriers encountered by lymphocytes entering breast tumors. We also review recent clinical trials of immunotherapy in breast cancer and provide a number of interesting questions that will need to be answered for successful breast cancer immunotherapy. © 2017, © The Author(s) 2017. |
| Keywords: | breast cancer; immunotherapy; immune evasion; tumor metabolism; tumor infiltrating lymphocytes |
| Journal Title: | Breast Cancer: Basic and Clinical Research |
| Volume: | 11 |
| ISSN: | 1178-2234 |
| Publisher: | Sage Publications |
| Date Published: | 2017-01-01 |
| Start Page: | 1178223417731565 |
| Language: | English |
| DOI: | 10.1177/1178223417731565 |
| PROVIDER: | scopus |
| PMCID: | PMC5617083 |
| PUBMED: | 28979132 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 1 May 2018 -- Source: Scopus |
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