Long-term renal function recovery following radical nephrectomy for kidney cancer: Results from a multicenter confirmatory study Journal Article


Authors: Zabor, E. C.; Furberg, H.; Lee, B.; Campbell, S.; Lane, B. R.; Thompson, R. H.; Antonio, E. C.; Noyes, S. L.; Zaid, H.; Jaimes, E. A.; Russo, P.
Article Title: Long-term renal function recovery following radical nephrectomy for kidney cancer: Results from a multicenter confirmatory study
Abstract: Purpose: We sought to confirm the findings from a previous single institution study of 572 patients from Memorial Sloan Kettering Cancer Center in which we found that 49% of patients recovered to the preoperative estimated glomerular filtration rate within 2 years following radical nephrectomy for renal cell carcinoma. Materials and Methods: A multicenter retrospective study was performed in 1,928 patients using data contributed from 3 independent centers. The outcome of interest was postoperative recovery to the preoperative estimated glomerular filtration rate. Data were analyzed using cumulative incidence and competing risks regression with death from any cause treated as a competing event. Results: This study demonstrated that 45% of patients had recovered to the preoperative estimated glomerular filtration rate by 2 years following radical nephrectomy. Furthermore, this study confirmed that recovery of renal function differed according to preoperative renal function such that patients with a lower preoperative estimated glomerular filtration rate had an increased chance of recovery. This study also suggested that larger tumor size and female gender were significantly associated with an increased chance of renal function recovery. Conclusions: In this multicenter retrospective study we confirmed that in the long term a large proportion of patients recover to preoperative renal function following radical nephrectomy for kidney tumors. Recovery is more likely among those with a lower preoperative estimated glomerular filtration rate. © 2018 American Urological Association Education and Research, Inc.
Keywords: creatinine; nephrectomy; kidney; carcinoma; renal cell; kidney function tests
Journal Title: Journal of Urology
Volume: 199
Issue: 4
ISSN: 0022-5347
Publisher: Elsevier Science, Inc.  
Date Published: 2018-04-01
Start Page: 921
End Page: 926
Language: English
DOI: 10.1016/j.juro.2017.10.027
PROVIDER: scopus
PUBMED: 29066363
DOI/URL:
Notes: Article -- Export Date: 2 April 2018 -- Source: Scopus
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MSK Authors
  1. Paul Russo
    436 Russo
  2. Emily Craig Zabor
    115 Zabor
  3. Edgar Alberto Jaimes
    23 Jaimes