Feasibility of a home-based exercise intervention with remote guidance for patients with stable grade II and III gliomas: A pilot randomized controlled trial Journal Article


Authors: Gehring, K.; Kloek, C. J. J.; Aaronson, N. K.; Janssen, K. W.; Jones, L. W.; Sitskoorn, M. M.; Stuiver, M. M.
Article Title: Feasibility of a home-based exercise intervention with remote guidance for patients with stable grade II and III gliomas: A pilot randomized controlled trial
Abstract: Objective: In this pilot study, we investigated the feasibility of a home-based, remotely guided exercise intervention for patients with gliomas. Design: Pilot randomized controlled trial (RCT) with randomization (2:1) to exercise or control group. Subjects: Patients with stable grade II and III gliomas. Intervention: The six-month intervention included three home-based exercise sessions per week at 60%–85% of maximum heart rate. Participants wore heart rate monitors connected to an online platform to record activities that were monitored weekly by the physiotherapist. Main measures: Accrual, attrition, adherence, safety, satisfaction, patient-reported physical activity, VO2 peak (by maximal cardiopulmonary exercise testing) and body mass index (BMI) at baseline and at six-month follow-up. Results: In all, 34 of 136 eligible patients (25%) were randomized to exercise training (N = 23) or the control group (N = 11), of whom 19 and 9, respectively, underwent follow-up. Mean adherence to prescribed sessions was 79%. Patients’ experiences were positive. There were no adverse events. Compared to the control group, the exercise group showed larger improvements in absolute VO2 peak (+158.9 mL/min; 95% CI: −44.8 to 362.5) and BMI (−0.3 kg/m²; 95% CI: −0.9 to 0.2). The median increase in physical activity was 1489 metabolic equivalent of task (MET) minutes higher in the exercise group. The most reported reasons for non-participation were lack of motivation or time. Conclusion: This innovative and intensive home-based exercise intervention was feasible in a small subset of patients with stable gliomas who were interested in exercising. The observed effects suggest that the programme may improve cardiorespiratory fitness. These results support the need for large-scale trials of exercise interventions in brain tumour patients. © 2017, © The Author(s) 2017.
Keywords: glioma; exercise; physical fitness; brain tumour; physical training
Journal Title: Clinical Rehabilitation
Volume: 32
Issue: 3
ISSN: 0269-2155
Publisher: Sage Publications, Inc  
Date Published: 2018-03-01
Start Page: 352
End Page: 366
Language: English
DOI: 10.1177/0269215517728326
PROVIDER: scopus
PUBMED: 28882061
PMCID: PMC6625754
DOI/URL:
Notes: Article -- Export Date: 2 April 2018 -- Source: Scopus
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  1. Lee Winston Jones
    143 Jones