The inverse electron-demand Diels-Alder reaction as a new methodology for the synthesis of (225)Ac-labelled radioimmunoconjugates Journal Article


Authors: Poty, S.; Membreno, R.; Glaser, J. M.; Ragupathi, A.; Scholz, W. W.; Zeglis, B. M.; Lewis, J. S.
Article Title: The inverse electron-demand Diels-Alder reaction as a new methodology for the synthesis of (225)Ac-labelled radioimmunoconjugates
Abstract: The inverse electron-demand Diels-Alder reaction between tetrazine (Tz) and trans-cyclooctene (TCO) facilitates the efficient radiosynthesis of 225Ac-labelled radioimmunoconjugates in a two-step method, outperforming conventional approaches based on isothiocyanate couplings. © 2018 The Royal Society of Chemistry.
Journal Title: Chemical Communications
Volume: 54
Issue: 21
ISSN: 1359-7345
Publisher: Royal Society of Chemistry  
Date Published: 2018-03-14
Start Page: 2599
End Page: 2602
Language: English
DOI: 10.1039/c7cc09129j
PROVIDER: scopus
PMCID: PMC5843558
PUBMED: 29388990
DOI/URL:
Notes: Article -- Export Date: 2 April 2018 -- Source: Scopus
Altmetric Score
MSK Authors
  1. Brian Zeglis
    63 Zeglis
  2. Jason S Lewis
    245 Lewis
  3. Sophie Poty
    7 Poty
  4. Jonathan Glaser
    2 Glaser