Peripheral blood clinical laboratory variables associated with outcomes following combination nivolumab and ipilimumab immunotherapy in melanoma Journal Article


Authors: Rosner, S.; Kwong, E.; Shoushtari, A. N.; Friedman, C. F.; Betof, A. S.; Brady, M. S.; Coit, D. G.; Callahan, M. K.; Wolchok, J. D.; Chapman, P. B.; Panageas, K. S.; Postow, M. A.
Article Title: Peripheral blood clinical laboratory variables associated with outcomes following combination nivolumab and ipilimumab immunotherapy in melanoma
Abstract: Both the combination of nivolumab + ipilimumab and single-agent anti-PD-1 immunotherapy have demonstrated survival benefit for patients with advanced melanoma. As the combination has a high rate of serious side effects, further analyses in randomized trials of combination versus anti-PD-1 immunotherapy are needed to understand who benefits most from the combination. Clinical laboratory values that were routinely collected in randomized studies may provide information on the relative benefit of combination immunotherapy. To prioritize which clinical laboratory factors to ultimately explore in these randomized studies, we performed a single-center, retrospective analysis of patients with advanced melanoma who received nivolumab + ipilimumab either as part of a clinical trial (n = 122) or commercial use (n = 87). Baseline routine laboratory values were correlated with overall survival (OS) and overall response rate (ORR). Kaplan–Meier estimation and Cox regression were performed. Median OS was 44.4 months, 95% CI (32.9, Not Reached). A total of 110 patients (53%) responded (CR/PR). Significant independent variables for favorable OS included the following: high relative eosinophils, high relative basophils, low absolute monocytes, low LDH, and a low neutrophil-to-lymphocyte ratio. These newly identified factors, along with those previously reported to be associated with anti-PD-1 monotherapy outcomes, should be studied in the randomized trials of nivolumab + ipilimumab versus anti-PD-1 monotherapies to determine whether they help define the patients who benefit most from the combination versus anti-PD-1 alone. © 2018 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.
Keywords: biomarkers; ipilimumab; immunotherapy; pd-1; nivolumab; prognosis; pembrolizumab
Journal Title: Cancer Medicine
Volume: 7
Issue: 3
ISSN: 2045-7634
Publisher: Wiley Blackwell  
Date Published: 2018-03-01
Start Page: 690
End Page: 697
Language: English
DOI: 10.1002/cam4.1356
PROVIDER: scopus
PMCID: PMC5852343
PUBMED: 29468834
DOI/URL:
Notes: Article -- Export Date: 2 April 2018 -- Source: Scopus
Altmetric Score
MSK Authors
  1. Jedd D Wolchok
    669 Wolchok
  2. Michael Andrew Postow
    187 Postow
  3. Paul Chapman
    252 Chapman
  4. Margaret Kathleen Callahan
    103 Callahan
  5. Katherine S Panageas
    331 Panageas
  6. Mary Sue Brady
    165 Brady
  7. Daniel Coit
    422 Coit
  8. Allison Betof Warner
    10 Warner