Association of preoperative breast MRI features with locoregional recurrence after breast conservation therapy Journal Article
| Authors: | Bae, M. S.; Chang, J. M.; Cho, N.; Han, W.; Ryu, H. S.; Moon, W. K. |
| Article Title: | Association of preoperative breast MRI features with locoregional recurrence after breast conservation therapy |
| Abstract: | Background: Locoregional recurrence (LRR) following breast conservation therapy (BCT) is associated with an increased risk of distant metastasis and death in patients with breast cancer. Purpose: To investigate whether preoperative breast magnetic resonance imaging (MRI) features are associated with the risk of LRR in patients undergoing BCT. Material and Methods: A total of 3781 women with primary invasive breast cancer underwent preoperative MRI and BCT between 2003 and 2013. Forty-eight patients who developed LRR comprised the LRR cohort and one-to-one matching (age, tumor stage, grade, and axillary nodal status) of each patient to a control participant was performed in patients who did not develop recurrence. Three readers independently reviewed MR images of the index cancer and the presence of multifocal disease was assessed. Χ2 analysis was used to compare imaging and clinical features between LRR and control cohorts, with multivariate logistic regression analysis used to identify independent features. Results: Significant differences were found in the proportion of multifocal disease (P = 0.001), background parenchymal enhancement level (P = 0.007), and breast cancer molecular subtype (P = 0.01) between LRR and control cohorts. Multivariate analysis showed that multifocal disease (odds ratio [OR] = 11.9; 95% confidence interval [CI] = 1.4–102.5; P = 0.02) and human epidermal growth factor receptor 2-positive subtype (OR = 12.7; 95% CI = 1.3–127.6; P = 0.03) were both independently associated with LRR. Conclusion: Multifocal disease on preoperative breast MRI may indicate an increased risk of LRR in patients treated with BCT. © 2017, © The Foundation Acta Radiologica 2017. |
| Keywords: | adult; controlled study; human tissue; middle aged; cancer surgery; primary tumor; retrospective studies; major clinical study; case control study; case-control studies; clinical feature; cancer localization; cancer recurrence; adjuvant therapy; cancer adjuvant therapy; cancer patient; cancer radiotherapy; preoperative care; cancer staging; nuclear magnetic resonance imaging; recurrence risk; magnetic resonance imaging; lymph node metastasis; antineoplastic agent; cancer grading; preoperative evaluation; reproducibility; reproducibility of results; neoplasm recurrence, local; breast cancer; breast; cohort analysis; recurrence; patient monitoring; pathology; diagnostic imaging; breast neoplasms; retrospective study; age; axillary lymph node; mammography; medical imaging; contrast enhancement; tumor recurrence; breast tumor; partial mastectomy; patient treatment; disease control; trastuzumab; regression analysis; multivariant analysis; breast surgery; image display; diseases; breast conservation therapy; mastectomy, segmental; chemoradiotherapy; her2; molecular pathology; magnetic resonance imaging (mri); procedures; human epidermal growth factor receptor 2 positive breast cancer; gadobenate dimeglumine; humans; human; female; priority journal; article; breast tissue |
| Journal Title: | Acta Radiologica |
| Volume: | 59 |
| Issue: | 4 |
| ISSN: | 0284-1851 |
| Publisher: | Sage Publications Ltd. |
| Date Published: | 2018-04-01 |
| Start Page: | 409 |
| End Page: | 417 |
| Language: | English |
| DOI: | 10.1177/0284185117723041 |
| PUBMED: | 28747131 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 2 April 2018 -- Source: Scopus |
