Cancer vaccines in pediatrics Book Section
| Authors: | Nakajima, M.; Modak, S. |
| Editors: | Gray, J. C.; Marabelle, A. |
| Article/Chapter Title: | Cancer vaccines in pediatrics |
| Abstract: | Cancer vaccines are antigen-specific biological agents that stimulate the immune system’s ability to fight malignancy. In children, cancer vaccines have the potential for far-reaching benefits while avoiding short and long-term toxicities associated with chemotherapy and radiotherapy. However, obstacles to their use in pediatrics include a paucity of tumor-specific antigens, severe chemotherapy-related immunosuppression, and relatively little interest in the pharmaceutical industry to devote major resources to develop immunotherapies for rare malignancies. Cancer vaccines seek to recruit a sustained cellular immune response against tumor antigens. This requires activation of CD4+ and CD8+ T-cells; in addition NK cell involvement is probably significant. In children with neuroblastoma the early success of a humoral vaccine suggests that B-cell responses are also important. In this chapter we focus on the current status of pediatric cancer vaccines with an emphasis on current and completed clinical trials, and on approaches that might inform future directions in their use. © Springer International Publishing Switzerland 2018. |
| Keywords: | cancer vaccines; neuroblastoma; pediatrics; active immunity |
| Book Title: | Immunotherapy for Pediatric Malignancies |
| ISBN: | 978-3-319-43484-1 |
| Publisher: | Springer International Publishing |
| Publication Place: | Cham, Switzerland |
| Date Published: | 2018-01-01 |
| Start Page: | 217 |
| End Page: | 242 |
| Language: | English |
| DOI: | 10.1007/978-3-319-43486-5_10 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Book Chapter: 10 -- Export Date: 2 April 2018 -- Source: Scopus |
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