Intracranial metastasis in fibrolamellar hepatocellular carcinoma Journal Article
| Authors: | Hammond, W. J.; Lalazar, G.; Saltsman, J. A.; Farber, B. A.; Danzer, E.; Sherpa, T. C.; Banda, C. D.; Andolina, J. R.; Karimi, S.; Brennan, C. W.; Torbenson, M. S.; La Quaglia, M. P.; Simon, S. M. |
| Article Title: | Intracranial metastasis in fibrolamellar hepatocellular carcinoma |
| Abstract: | Fibrolamellar hepatocellular carcinoma (FLHCC) is a rare liver malignancy in adolescents and young adults. Surgery is the mainstay of therapy for primary and metastatic disease. Most patients relapse, with development of both local and distant metastases. Brain metastases from solid tumors are rare in the pediatric and young adult population. Here, we document three patients with brain metastases from FLHCC, confirmed by histology and molecular characterization of the chimeric fusion DNAJB1–PRKACA, each necessitating neurosurgical intervention. These observations highlight the ability of FLHCC to metastasize to the brain and suggest the need for surveillance neuroimaging for patients with advanced-stage disease. © 2017 Wiley Periodicals, Inc. |
| Keywords: | tumor biology; liver; brain; tumors; fibrolamellar; rare tumors; adolescent and young adult tumors |
| Journal Title: | Pediatric Blood and Cancer |
| Volume: | 65 |
| Issue: | 4 |
| ISSN: | 1545-5009 |
| Publisher: | Wiley Periodicals, Inc |
| Date Published: | 2018-04-01 |
| Start Page: | e26919 |
| Language: | English |
| DOI: | 10.1002/pbc.26919 |
| PROVIDER: | scopus |
| PUBMED: | 29286561 |
| PMCID: | PMC6028006 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 March 2018 -- Source: Scopus |
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