Intraductal papillary mucinous neoplasm of the pancreas in young patients: Tumor biology, clinical features, and survival outcomes Journal Article


Authors: Morales-Oyarvide, V.; Mino-Kenudson, M.; Ferrone, C. R.; Warshaw, A. L.; Lillemoe, K. D.; Sahani, D. V.; Pergolini, I.; Attiyeh, M. A.; Al Efishat, M.; Rezaee, N.; Hruban, R. H.; He, J.; Weiss, M. J.; Allen, P. J.; Wolfgang, C. L.; Fernández-del Castillo, C.
Article Title: Intraductal papillary mucinous neoplasm of the pancreas in young patients: Tumor biology, clinical features, and survival outcomes
Abstract: Aim: The aim of this paper is to describe the characteristics of intraductal papillary mucinous neoplasms (IPMNs) of the pancreas in young patients. Methods: We evaluated 1693 patients from the Pancreatic Surgery Consortium who underwent resection for IPMN and classified them as younger or older than 50 years of age at the time of surgery. We assessed the relationship of age with clinical, radiological, pathological, and prognostic features. Results: We identified 90 (5%) young patients. Age was not associated with differences in main pancreatic duct size (P = 0.323), presence of solid components (P = 0.805), or cyst size (P = 0.135). IPMNs from young patients were less likely to be of gastric type (37 vs. 57%, P = 0.005), and more likely to be of oncocytic (15 vs. 4%, P = 0.003) and intestinal types (44 vs. 26%, P = 0.004). Invasive carcinomas arising from IPMN were less common in young patients (17 vs. 27%, P = 0.044), and when present they were commonly of colloid type (47 vs. 31% in older patients, P = 0.261) and had better overall survival than older patients (5-year, 71 vs. 37%, log-rank P = 0.031). Conclusion: Resection for IPMN is infrequent in young patients, but when they are resected, IPMNs from young patients demonstrate different epithelial subtypes from those in older patients and more favorable prognosis. © 2017, The Society for Surgery of the Alimentary Tract.
Keywords: young; ipmn; pancreatic cystic neoplasms
Journal Title: Journal of Gastrointestinal Surgery
Volume: 22
Issue: 2
ISSN: 1091-255X
Publisher: Springer  
Date Published: 2018-02-01
Start Page: 226
End Page: 234
Language: English
DOI: 10.1007/s11605-017-3602-z
PROVIDER: scopus
PUBMED: 29047068
DOI/URL:
Notes: Article -- Export Date: 1 March 2018 -- Source: Scopus
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MSK Authors
  1. Peter Allen
    440 Allen
  2. Marc   Attiyeh
    22 Attiyeh