Ovarian cancer risk, ALDH2 polymorphism and alcohol drinking: Asian data from the Ovarian Cancer Association Consortium Journal Article
| Authors: | Ugai, T.; Kelemen, L. E.; Mizuno, M.; Ong, J. S.; Webb, P. M.; Chenevix-Trench, G.; on behalf of the Australian Ovarian Cancer Study Group; Wicklund, K. G.; Doherty, J. A.; Rossing, M. A.; Thompson, P. J.; Wilkens, L. R.; Carney, M. E.; Goodman, M. T.; Schildkraut, J. M.; Berchuck, A.; Cramer, D. W.; Terry, K. L.; Cai, H.; Shu, X. O.; Gao, Y. T.; Xiang, Y. B.; Van Den Berg, D.; Pike, M. C.; Wu, A. H.; Pearce, C. L.; Matsuo, K.; on behalf of the Ovarian Cancer Association Consortium |
| Article Title: | Ovarian cancer risk, ALDH2 polymorphism and alcohol drinking: Asian data from the Ovarian Cancer Association Consortium |
| Abstract: | The aldehyde dehydrogenase 2 (ALDH2) polymorphism rs671 (Glu504Lys) causes ALDH2 inactivation and adverse acetaldehyde exposure among Asians, but little is known of the association between alcohol consumption and rs671 and ovarian cancer (OvCa) in Asians. We conducted a pooled analysis of Asian ancestry participants in the Ovarian Cancer Association Consortium. We included seven case-control studies and one cohort study comprising 460 invasive OvCa cases, 37 borderline mucinous OvCa and 1274 controls of Asian descent with information on recent alcohol consumption. Pooled odds ratios (OR) with 95% confidence intervals (CI) for OvCa risk associated with alcohol consumption, rs671 and their interaction were estimated using logistic regression models adjusted for potential confounders. No significant association was observed for daily alcohol intake with invasive OvCa (OR comparing any consumption to none = 0.83; 95% CI = 0.58-1.18) or with individual histotypes. A significant decreased risk was seen for carriers of one or both Lys alleles of rs671 for invasive mucinous OvCa (OR = 0.44; 95% CI = 0.20-0.97) and for invasive and borderline mucinous tumors combined (OR = 0.48; 95% CI = 0.26-0.89). No significant interaction was observed between alcohol consumption and rs671 genotypes. In conclusion, self-reported alcohol consumption at the quantities estimated was not associated with OvCa risk among Asians. Because the rs671 Lys allele causes ALDH2 inactivation leading to increased acetaldehyde exposure, the observed inverse genetic association with mucinous ovarian cancer is inferred to mean that alcohol intake may be a risk factor for this histotype. This association will require replication in a larger sample. © 2017 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association. |
| Keywords: | adult; controlled study; aged; major clinical study; single nucleotide polymorphism; case control study; genetics; polymorphism, single nucleotide; cancer risk; ovarian cancer; ovarian neoplasms; allele; genetic predisposition to disease; ovary cancer; cohort studies; logistic models; adenocarcinoma, mucinous; cohort analysis; genetic association; genotype; odds ratio; heterozygote; risk factor; self report; ovary tumor; alcohol; enzyme inactivation; medical society; alcohol consumption; colloid carcinoma; genetic predisposition; statistical model; alcohol drinking; drinking behavior; genetic polymorphism; asian continental ancestry group; association; asian; pooled analysis; ancestry group; acetaldehyde; genetic association studies; very elderly; humans; human; female; priority journal; article; genetic association study; aldh2; drinking habit; aldehyde dehydrogenase isoenzyme 2; aldh2 protein, human; aldehyde dehydrogenase, mitochondrial |
| Journal Title: | Cancer Science |
| Volume: | 109 |
| Issue: | 2 |
| ISSN: | 1347-9032 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2018-02-01 |
| Start Page: | 435 |
| End Page: | 445 |
| Language: | English |
| DOI: | 10.1111/cas.13470 |
| PUBMED: | 29247577 |
| PROVIDER: | scopus |
| PMCID: | PMC5797830 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 March 2018 -- Source: Scopus |
