Non coding RNA analysis in fibrolamellar hepatocellular carcinoma Journal Article


Authors: Farber, B. A.; Lalazar, G.; Simon, E. P.; Hammond, W. J.; Requena, D.; Bhanot, U. K.; La Quaglia, M. P.; Simon, S. M.
Article Title: Non coding RNA analysis in fibrolamellar hepatocellular carcinoma
Abstract: Fibrolamellar hepatocellular carcinoma (FLC) is a rare primary liver cancer found in adolescents and young adults without underlying liver disease. A deletion of ~400 kD has been found in one copy of chromosome 19 in the tumor tissue of all patients tested. This produces a fusion of the genes DNAJB1 and PRKACA which, in turn, produces a chimeric transcript and protein. Transcriptomic analysis of the tumor has shown upregulation of various oncologically relevant pathways, including EGF/ ErbB, Aurora Kinase A, pak21 and wnt. To explore other factors that may contribute to oncogenesis, we examined the microRNA (miRNA) and long non-coding RNA (lncRNA) expression in FLC. The non-coding RNA expression profile in tumor tissue samples is distinctly different from the adjacent normal liver and from other liver tumors. Furthermore, miRZip knock down or over expression of certain miRNAs led to changes in the levels of coding genes that recapitulated changes observed in FLC, suggesting mechanistically that the changes in the cellular levels of miRNA are not merely correlative. Thus, in addition to serving as diagnostic tools for FLC, non-coding RNAs may serve as therapeutic targets. © Farber et al.
Keywords: microrna; liver cancer; fusion protein; pediatric cancer; lncrnas
Journal Title: Oncotarget
Volume: 9
Issue: 12
ISSN: 1949-2553
Publisher: Impact Journals  
Date Published: 2018-02-13
Start Page: 10211
End Page: 10227
Language: English
DOI: 10.18632/oncotarget.23325
PROVIDER: scopus
PMCID: PMC5828204
PUBMED: 29535801
DOI/URL:
Notes: Article -- Export Date: 1 March 2018 -- Source: Scopus
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MSK Authors
  1. Umeshkumar Kapaldev Bhanot
    42 Bhanot
  2. Benjamin Asher Farber
    12 Farber