Effect of age on response to therapy and mortality in patients with thyroid cancer at high risk of recurrence Journal Article
| Authors: | Shah, S.; Boucai, L. |
| Article Title: | Effect of age on response to therapy and mortality in patients with thyroid cancer at high risk of recurrence |
| Abstract: | Context: Age at diagnosis has been identified as a major determinant of thyroid cancer-specific survival, with older patients being at higher risk for mortality, but the association of age with risk of recurrence has not been studied to date. Objective: To examine the effect of a patient's age on response to therapy and disease-specific mortality in a cohort of thyroid cancer patients at high risk of recurrence, as defined by the American Thyroid Association (ATA) risk stratification system. Design: Retrospective cohort study of 320 patients, median age 49.3 years, with follicular cellderived thyroid carcinoma classified at ATA high risk and followed for a median of 7 years. Main Outcome Measures: Association of age with response to therapy, overall mortality, diseasespecific mortality, and timing of metastases. Results: Age was a major determinant of response to therapy. There was a significantly larger percentage of excellent responders among young patients (age ,55) than among old patients (age $55), 40.3% vs 27.5%, P = 0.002, respectively, whereas the proportion of structural incomplete responders was higher in the old group compared with the young group, 53% vs 33%, P = 0.002, respectively. ATA high-risk young patients with a structural incomplete response to therapy had a significantly better disease-specific survival than old patients (74% vs 12%, P < 0.001, respectively). Conclusions: Age was a key predictor of response to therapy and disease-specific survival in ATA high-risk thyroid cancer patients. Its incorporation as a variable in the ATA risk stratification system would improve its power to predict response to therapy as well as mortality. Copyright © 2018 Endocrine Society. |
| Journal Title: | Journal of Clinical Endocrinology and Metabolism |
| Volume: | 103 |
| Issue: | 2 |
| ISSN: | 0021-972X |
| Publisher: | Oxford University Press |
| Date Published: | 2018-02-01 |
| Start Page: | 689 |
| End Page: | 697 |
| Language: | English |
| DOI: | 10.1210/jc.2017-02255 |
| PROVIDER: | scopus |
| PMCID: | PMC5800839 |
| PUBMED: | 29220531 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 March 2018 -- Source: Scopus |
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