Inter-operator variability in compartmental kinetic analysis of (18)F-fluoromisonidazole dynamic PET Journal Article


Authors: Nehmeh, S. A.; Schwartz, J.; Grkovski, M.; Yeung, I.; Laymon, C. M.; Muzi, M.; Humm, J. L.
Article Title: Inter-operator variability in compartmental kinetic analysis of (18)F-fluoromisonidazole dynamic PET
Abstract: Purpose: To assess the inter-operator variability in compartment analysis (CA) of dynamic-FMISO (dyn-FMISO) PET. Methods: Study-I: Five investigators conducted CA for 23 NSCLC dyn-FMISO tumor time-activity-curves. Study-II: Four operators performed CA for four NSCLC dyn-FMISO datasets. Repeatability of Kinetic-Rate-Constants (KRCs) was assessed. Results: Study-I: Strong correlation (ICC > 0.9) and interchangeable results among operators existed for all KRCs. Study-II: Up to 103% variability in tumor segmentation, and weaker ICC in KRCs (ICC-VB = 0.53; ICC-K1 = 0.91; ICC-K1/k2 = 0.25; ICC-k3 = 0.32; ICC-Ki = 0.54) existed. All KRCs were repeatable among the different operators. Conclusions: Inter-operator variability in CA of dyn-FMISO was shown to be within statistical errors. © 2017
Keywords: clinical article; positron emission tomography; kinetics; tumors; 1 fluoro 3 (2 nitro 1 imidazolyl) 2 propanol f 18; kinetic analysis; rate constants; correlational study; dynamic pet; time-activity curves; non small cell lung cancer; variability; clinical target volume; image segmentation; tumor blood flow; operator; strong correlation; tumor segmentation; human; priority journal; article; measurement repeatability; compartment analysis; kinetic rate constants
Journal Title: Clinical Imaging
Volume: 49
ISSN: 0899-7071
Publisher: Elsevier Inc.  
Date Published: 2018-05-01
Start Page: 121
End Page: 127
Language: English
DOI: 10.1016/j.clinimag.2017.12.015
PROVIDER: scopus
PUBMED: 29414505
DOI/URL:
Notes: Article -- Export Date: 1 March 2018 -- Source: Scopus
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  1. John Laurence Humm
    337 Humm