Prostate-specific antigen velocity in a prospective prostate cancer screening study of men with genetic predisposition Journal Article


Authors: Mikropoulos, C.; Hutten Selkirk, C. G.; Saya, S.; Bancroft, E.; Vertosick, E.; Dadaev, T.; Brendler, C.; Page, E.; Dias, A.; Evans, D. G.; Rothwell, J.; Maehle, L.; Axcrona, K.; Richardson, K.; Eccles, D.; Jensen, T.; Osther, P. J.; van Asperen, C. J.; Vasen, H.; Kiemeney, L. A.; Ringelberg, J.; Cybulski, C.; Wokolorczyk, D.; Hart, R.; Glover, W.; Lam, J.; Taylor, L.; Salinas, M.; Feliubadaló, L.; Oldenburg, R.; Cremers, R.; Verhaegh, G.; van Zelst-Stams, W. A.; Oosterwijk, J. C.; Cook, J.; Rosario, D. J.; Buys, S. S.; Conner, T.; Domchek, S.; Powers, J.; Ausems, M. G. E. M.; Teixeira, M. R.; Maia, S.; Izatt, L.; Schmutzler, R.; Rhiem, K.; Foulkes, W. D.; Boshari, T.; Davidson, R.; Ruijs, M.; Helderman-van den Enden, A. T. J. M.; Andrews, L.; Walker, L.; Snape, K.; Henderson, A.; Jobson, I.; Lindeman, G. J.; Liljegren, A.; Harris, M.; Adank, M. A.; Kirk, J.; Taylor, A.; Susman, R.; Chen-Shtoyerman, R.; Pachter, N.; Spigelman, A.; Side, L.; Zgajnar, J.; Mora, J.; Brewer, C.; Gadea, N.; Brady, A. F.; Gallagher, D.; van Os, T.; Donaldson, A.; Stefansdottir, V.; Barwell, J.; James, P. A.; Murphy, D.; Friedman, E.; Nicolai, N.; Greenhalgh, L.; Obeid, E.; Murthy, V.; Copakova, L.; McGrath, J.; Teo, S. H.; Strom, S.; Kast, K.; Leongamornlert, D. A.; Chamberlain, A.; Pope, J.; Newlin, A. C.; Aaronson, N.; Ardern-Jones, A.; Bangma, C.; Castro, E.; Dearnaley, D.; Eyfjord, J.; Falconer, A.; Foster, C. S.; Gronberg, H.; Hamdy, F. C.; Johannsson, O.; Khoo, V.; Lubinski, J.; Grindedal, E. M.; McKinley, J.; Shackleton, K.; Mitra, A. V.; Moynihan, C.; Rennert, G.; Suri, M.; Tricker, K.; IMPACT study collaborators; Moss, S.; Kote-Jarai, Z.; Vickers, A.; Lilja, H.; Helfand, B. T.; Eeles, R. A.
Article Title: Prostate-specific antigen velocity in a prospective prostate cancer screening study of men with genetic predisposition
Abstract: Background:Prostate-specific antigen (PSA) and PSA-velocity (PSAV) have been used to identify men at risk of prostate cancer (PrCa). The IMPACT study is evaluating PSA screening in men with a known genetic predisposition to PrCa due to BRCA1/2 mutations. This analysis evaluates the utility of PSA and PSAV for identifying PrCa and high-grade disease in this cohort.Methods:PSAV was calculated using logistic regression to determine if PSA or PSAV predicted the result of prostate biopsy (PB) in men with elevated PSA values. Cox regression was used to determine whether PSA or PSAV predicted PSA elevation in men with low PSAs. Interaction terms were included in the models to determine whether BRCA status influenced the predictiveness of PSA or PSAV.Results:1634 participants had 3/43 PSA readings of whom 174 underwent PB and 45 PrCas diagnosed. In men with PSA >3.0 ng ml -l, PSAV was not significantly associated with presence of cancer or high-grade disease. PSAV did not add to PSA for predicting time to an elevated PSA. When comparing BRCA1/2 carriers to non-carriers, we found a significant interaction between BRCA status and last PSA before biopsy (P=0.031) and BRCA2 status and PSAV (P=0.024). However, PSAV was not predictive of biopsy outcome in BRCA2 carriers.Conclusions:PSA is more strongly predictive of PrCa in BRCA carriers than non-carriers. We did not find evidence that PSAV aids decision-making for BRCA carriers over absolute PSA value alone.
Keywords: adult; controlled study; human tissue; middle aged; gene mutation; major clinical study; cancer risk; prospective study; prostate specific antigen; cohort analysis; cancer screening; brca1 protein; brca2 protein; heterozygote; prostate cancer; prostate biopsy; genetic risk; genetic predisposition; prostate specific antigen velocity; cancer prognosis; human; male; priority journal; article; male genital tract parameters
Journal Title: British Journal of Cancer
Volume: 118
Issue: 2
ISSN: 0007-0920
Publisher: Nature Publishing Group  
Date Published: 2018-01-23
Start Page: 266
End Page: 276
Language: English
DOI: 10.1038/bjc.2017.429
PROVIDER: scopus
PMCID: PMC5785754
PUBMED: 29301143
DOI/URL:
Notes: Article -- Export Date: 1 March 2018 -- Source: Scopus
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MSK Authors
  1. Hans Gosta Lilja
    286 Lilja
  2. Andrew J Vickers
    565 Vickers